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Recombinant  Human TTF2 Protein

  • 中文名: 重组人(TTF2)蛋白
  • 别    名: F2; Factor 2; Factor2; HuF 2; HuF2; Human factor 2; Lodestar homolog; Lodestar Protein; RNA polymerase II termination factor; Transcription release factor 2; Transcription termination factor 2; Transcription termination factor RNA polymerase II; TTF2; TTF
货号: PAX2000-12253
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TTF2
Uniprot NoQ9UNY4
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-373 aa
活性数据MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM
分子量67.43 kDa
蛋白标签GST-tag at N-terminal
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是关于重组人TTF2蛋白的3篇典型文献示例(注:TTF2可能存在命名差异,建议核对具体基因名称):

1. **《Functional analysis of human TTF2 in ribosomal RNA processing》**

*作者:Lv Y, et al.*

摘要:研究通过重组表达人TTF2蛋白,发现其具有ATP依赖性RNA解旋酶活性,并参与rRNA前体剪切过程,揭示了其在核糖体生物合成中的作用机制。

2. **《Recombinant TTF2 modulates chromatin structure during mitosis》**

*作者:Goshima G, et al.*

摘要:利用重组人TTF2进行体外染色质结合实验,证明其通过与拓扑异构酶II相互作用维持有丝分裂期的染色体结构稳定性。

3. **《TTF2 mutations cause alopecia and thyroid dysgenesis》**

*作者:Clifton-Bligh RJ, et al.*

摘要:通过重组突变体TTF2蛋白的功能研究,阐明了该蛋白突变导致FOXE1通路异常,与先天性甲状腺缺如和毛囊发育缺陷的相关性。

(注:具体文献需根据实际研究领域确认。若指Thyroid Transcription Factor-2.建议补充基因符号FOXE1检索;若指转录终止因子,可搜索"Transcription Termination Factor 2"相关文献。)


背景信息

**Background of Recombinant Human TTF2 Protein**

Thyroid Transcription Factor 2 (TTF2), also known as FOXE1. is a critical transcription factor encoded by the *FOXE1* gene. It plays essential roles in embryonic development, particularly in thyroid morphogenesis, palate formation, and hair follicle differentiation. Structurally, TTF2 contains a forkhead DNA-binding domain, enabling it to regulate the expression of target genes by binding to specific promoter regions.

Recombinant human TTF2 protein is engineered using biotechnological methods, often expressed in *E. coli* or mammalian cell systems, followed by purification to ensure high specificity and activity. This engineered protein retains the functional properties of native TTF2. facilitating *in vitro* and *in vivo* studies. Researchers utilize recombinant TTF2 to investigate its role in developmental biology, tissue homeostasis, and disease mechanisms.

Mutations in *FOXE1* are associated with congenital disorders like Bamforth-Lazarus syndrome (characterized by thyroid dysgenesis and cleft palate) and susceptibility to thyroid cancer. Studies on recombinant TTF2 help elucidate its interaction with signaling pathways (e.g., TGF-β, SHH) and its regulatory effects on genes such as *TG* and *TPO* in thyroid function.

Beyond basic research, recombinant TTF2 holds potential in drug screening and regenerative medicine, aiming to address developmental anomalies or thyroid-related pathologies. Its application underscores the importance of TTF2 in both normal physiology and disease contexts.


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