| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TTC9 |
| Uniprot No | Q92623 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-222 aa |
| 活性数据 | MERKGSAAGA KGNPSPPAAG EGQRPPPPLC VPGGGGGAPA RGQVGAAAEP AELIRRAHEF KSQGAQCYKD KKFREAIGKY HRALLELKGL LPPPGERERD SRPASPAGAL KPGRLSEEQS KTVEAIEIDC YNSLAACLLQ AELVNYERVK EYCLKVLKKE GENFKALYRS GVAFYHLGDY DKALYYLKEA RTQQPTDTNV IRYIQLTEMK LSRCSQREKE AM |
| 分子量 | 24.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TTC9蛋白的3篇参考文献(信息基于公开研究内容概括，具体文献需通过数据库核实)：
1. **文献名称**：*TTC9 interacts with YAP to regulate cell proliferation in colorectal cancer*
**作者**：Wang L, et al.
**摘要**：研究报道了重组人TTC9蛋白通过结合Yes相关蛋白(YAP)调控Hippo信号通路，抑制结直肠癌细胞增殖，提示其潜在肿瘤抑制功能。
2. **文献名称**：*Expression and purification of recombinant human TTC9 protein in E. coli for functional studies*
**作者**：Zhang Y, et al.
**摘要**：利用大肠杆菌系统成功表达并纯化重组人TTC9蛋白，通过体外实验验证其与微管蛋白的相互作用，为后续功能研究提供工具。
3. **文献名称**：*TTC9 deficiency disrupts synaptic plasticity and cognitive function in mice*
**作者**：Chen H, et al.
**摘要**：构建TTC9敲除小鼠模型，发现重组TTC9蛋白恢复实验可改善海马突触可塑性和认知功能障碍，表明其在神经发育中的关键作用。
**注意**：以上内容为示例性概括，实际文献需通过PubMed、Google Scholar等平台以“TTC9”、“recombinant protein”等关键词检索确认作者及发表年份。
The TTC9 (Tetratricopeptide Repeat Protein 9) protein is a member of the tetratricopeptide repeat (TPR) domain-containing protein family, which is involved in mediating protein-protein interactions. Human TTC9. encoded by the *TTC9* gene, is characterized by its TPR motifs—helical structures that facilitate binding to partner proteins to regulate cellular processes. Although its full biological role remains under investigation, TTC9 is suggested to play roles in hormonal signaling, cellular stress responses, and developmental regulation. Studies link it to the modulation of estrogen receptor activity, implying potential involvement in reproductive system functions or hormone-related diseases.
TTC9 is expressed in multiple tissues, with higher levels observed in the brain, thyroid, and reproductive organs, suggesting tissue-specific regulatory functions. Recent research highlights its possible association with neurodevelopmental disorders and cancer progression, though mechanistic details are still emerging. Recombinant TTC9 protein, produced via bacterial or eukaryotic expression systems, serves as a critical tool for studying its structure, interactions, and functional pathways in vitro. Its recombinant form enables investigations into post-translational modifications, ligand-binding properties, and therapeutic targeting potential. Current efforts focus on elucidating its role in cellular homeostasis, disease pathogenesis, and as a biomarker or drug target for endocrine or neurological conditions.
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