| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PSRC2 |
| Uniprot No | O60293 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-358 aa |
| 活性数据 | MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGIPYRVKEGFTPIPGLKFSA |
| 分子量 | 65.12 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PSRC2蛋白的参考文献示例(注：以下内容为模拟示例，非真实文献)：
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1. **文献名称**: *PSRC2 modulates cell cycle progression via interaction with Cyclin B1*
**作者**: Zhang L, et al.
**摘要**: 本研究通过表达重组人PSRC2蛋白，揭示了其与Cyclin B1的直接互作，并证明该相互作用通过调控CDK1活性影响细胞周期G2/M期转换。体外实验表明PSRC2的缺失导致有丝分裂延迟。
2. **文献名称**: *Recombinant human PSRC2 inhibits apoptosis in cardiomyocytes under oxidative stress*
**作者**: Tanaka K, et al.
**摘要**: 利用重组PSRC2蛋白处理心肌细胞，发现其通过激活Akt信号通路减轻氧化应激诱导的凋亡，提示PSRC2在心脏保护中的潜在治疗价值。
3. **文献名称**: *Crystal structure and biophysical characterization of the coiled-coil domain of PSRC2*
**作者**: Müller S, et al.
**摘要**: 本研究通过大肠杆菌系统表达并纯化重组PSRC2蛋白的卷曲螺旋结构域，利用X射线晶体学解析其高分辨率结构，揭示其在蛋白寡聚化中的关键作用。
4. **文献名称**: *PSRC2 knockdown impairs adipogenesis via Wnt signaling dysregulation*
**作者**: Park S, et al.
**摘要**: 通过体外重组PSRC2蛋白回补实验，验证了其在脂肪细胞分化中对Wnt/β-catenin信号通路的调控作用，表明PSRC2是脂肪生成的关键调节因子。
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如需真实文献，建议在PubMed或Google Scholar以“PSRC2 recombinant protein”或“PSRC2 expression and function”为关键词检索最新研究。当前关于PSRC2的研究仍有限，可能需结合其相互作用蛋白或相关通路进行扩展分析。
PSRC2 (Proline and Serine-Rich Coiled-Coil Protein 2), encoded by the PSRC2 gene in humans, is a poorly characterized protein implicated in diverse cellular processes. Its structure features a central coiled-coil domain flanked by proline- and serine-rich regions, suggesting roles in protein-protein interactions and signaling. Studies link PSRC2 to cell cycle regulation, with potential involvement in mitosis and chromatin dynamics, though exact mechanisms remain unclear. It shows tissue-specific expression patterns, with higher levels detected in testis, brain, and immune cells.
Recombinant human PSRC2 protein is typically produced using bacterial (E. coli) or mammalian expression systems, enabling functional studies. As a research tool, it facilitates investigations into PSRC2's binding partners, post-translational modifications (particularly phosphorylation at serine-rich domains), and subcellular localization. Emerging evidence associates PSRC2 dysregulation with cancers and neurodevelopmental disorders, positioning it as a potential biomarker or therapeutic target. Its coiled-coil architecture and nuclear-cytoplasmic shuttling behavior suggest possible roles in chromatin remodeling or transcriptional regulation. Current research focuses on mapping its interactome and delineating its contribution to cellular proliferation and differentiation pathways.
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