| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NUDCD1 |
| Uniprot No | Q96RS6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-583 aa |
| 活性数据 | MEVAANCSLR VKRPLLDPRF EGYKLSLEPL PCYQLELDAA VAEVKLRDDQ YTLEHMHAFG MYNYLHCDSW YQDSVYYIDT LGRIMNLTVM LDTALGKPRE VFRLPTDLTA CDNRLCASIH FSSSTWVTLS DGTGRLYVIG TGERGNSASE KWEIMFNEEL GDPFIIIHSI SLLNAEEHSI ATLLLRIEKE ELDMKGSGFY VSLEWVTISK KNQDNKKYEI IKRDILRGKS VPHYAAIEPD GNGLMIVSYK SLTFVQAGQD LEENMDEDIS EKIKEPLYYW QQTEDDLTVT IRLPEDSTKE DIQIQFLPDH INIVLKDHQF LEGKLYSSID HESSTWIIKE SNSLEISLIK KNEGLTWPEL VIGDKQGELI RDSAQCAAIA ERLMHLTSEE LNPNPDKEKP PCNAQELEEC DIFFEESSSL CRFDGNTLKT THVVNLGSNQ YLFSVIVDPK EMPCFCLRHD VDALLWQPHS SKQDDMWEHI ATFNALGYVQ ASKRDKKFFA CAPNYSYAAL CECLRRVFIY RQPAPMSTVL YNRKEGRQVG QVAKQQVASL ETNDPILGFQ ATNERLFVLT TKNLFLIKVN TEN |
| 分子量 | 66.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是三篇涉及NUDCD1蛋白功能的代表性文献示例(注：以下文献信息为模拟生成，实际引用请通过PubMed等数据库核实)：
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1. **文献名称**：NUDCD1 regulates leukemogenesis through modulating pre-mRNA splicing in acute myeloid leukemia
**作者**：Li, Y., et al.
**摘要**：本研究发现NUDCD1在急性髓系白血病(AML)中异常高表达，通过重组蛋白实验证实其通过调控RNA剪接因子相互作用，促进肿瘤细胞增殖并抑制凋亡。
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2. **文献名称**：Structural and functional analysis of NUDCD1 in the IL-23 signaling pathway
**作者**：Wang, Q., et al.
**摘要**：利用重组NUDCD1蛋白进行结构解析，揭示了其在IL-23受体复合物中的结合位点，证明其通过调节IL-23信号通路参与自身免疫性疾病发生机制。
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3. **文献名称**：NUDCD1 deficiency causes developmental arrest via disrupting Hedgehog signaling
**作者**：Zhang, R., et al.
**摘要**：通过基因敲除和重组蛋白回补实验，发现NUDCD1缺失会导致胚胎发育异常，机制涉及Hedgehog信号通路关键蛋白的稳定性调控。
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**说明**：NUDCD1研究目前多集中于癌症、发育和免疫领域，但直接聚焦重组蛋白功能的文献较少。建议结合关键词"NUDCD1 recombinant protein"或"NUDCD1 purification"在PubMed/Google Scholar进一步检索最新成果。
**Background of Recombinant Human NUDCD1 Protein**
NUDCD1 (NudC domain-containing protein 1) is a conserved eukaryotic protein implicated in diverse cellular processes, including nuclear migration, cell cycle regulation, and cytoskeletal organization. As a member of the NudC family, it shares structural homology with NudC, a key regulator of nuclear movement during fungal development, suggesting evolutionary conservation in managing nuclear-cytoskeletal interactions. Human NUDCD1 is ubiquitously expressed across tissues and plays roles in mitotic progression, potentially influencing spindle assembly and chromosome segregation.
Studies link NUDCD1 to cellular stress responses, apoptosis, and DNA repair pathways. Notably, its dysregulation is associated with pathological conditions, such as cancer, where altered expression correlates with tumor proliferation, metastasis, and chemoresistance. It may also interact with signaling molecules like STAT3. hinting at roles in immune regulation and oncogenic pathways.
Recombinant NUDCD1 protein, typically produced via bacterial or mammalian expression systems, serves as a critical tool for studying its biochemical properties, interactome, and mechanistic contributions to diseases. Purified variants (e.g., tagged or truncated forms) enable functional assays, antibody development, and structural analyses. Current research focuses on clarifying its precise molecular functions, post-translational modifications, and therapeutic potential as a biomarker or target in precision medicine. Despite progress, many aspects of NUDCD1 biology remain enigmatic, necessitating further exploration.
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