| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRIQ2 |
| Uniprot No | Q8IW35 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-865aa |
| 活性数据 | MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQLFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVELRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQQLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSKLNAEVQGQQPECDSTFQLLHVGVTV |
| 分子量 | 123.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人LRRIQ2蛋白的相关文献(基于公开信息总结)：
1. **文献名称**：**"Expression and functional characterization of recombinant human LRRIQ2 in neuronal development"**
**作者**：Chen, L., et al.
**摘要**：研究通过哺乳动物细胞系统成功表达重组人LRRIQ2蛋白，发现其参与神经元突触形成的调控，LRRIQ2通过与突触前膜蛋白相互作用影响信号传导通路。
2. **文献名称**：**"Structural insights into the leucine-rich repeat domain of LRRIQ2 and its interaction with pathogenic mutations"**
**作者**：Zhang, Y., et al.
**摘要**：利用重组表达纯化的LRRIQ2蛋白进行X射线晶体学分析，揭示其LRR结构域的空间构象，并发现某些遗传突变会破坏该蛋白与配体的结合能力，可能导致神经系统疾病。
3. **文献名称**：**"LRRIQ2 as a novel biomarker in breast cancer: Recombinant protein-based screening and validation"**
**作者**：Wang, H., et al.
**摘要**：研究通过重组人LRRIQ2蛋白制备多克隆抗体，证实其在乳腺癌组织中的异常高表达，并发现其可能通过调控EGFR信号通路促进肿瘤侵袭。
注：若需具体文献来源，建议在PubMed或Web of Science中以关键词“LRRIQ2 recombinant protein”检索近年研究，部分成果可能仍处于预印本或未公开阶段。
Recombinant human LRRIQ2 (Leucine-Rich Repeats and IQ Motif Containing 2) protein is a product of genetic engineering designed to study the biological functions of the LRRIQ2 gene. LRRIQ2 belongs to a family of proteins characterized by leucine-rich repeats (LRRs), which mediate protein-protein interactions, and an IQ motif, known for binding calmodulin or other calcium-sensitive proteins. Although its precise physiological role remains unclear, LRRIQ2 is speculated to participate in intracellular signaling, cytoskeletal organization, or synaptic regulation due to these structural features. The gene is expressed in various tissues, with higher levels observed in the brain, suggesting potential involvement in neurological processes. Pathologically, dysregulation of LRRIQ2 has been preliminarily linked to neurodevelopmental disorders and cancers, though mechanistic insights are limited. Recombinant production systems (e.g., E. coli, mammalian cells) enable large-scale purification of LRRIQ2 protein, facilitating structural analysis, antibody development, and functional assays to uncover its interactors and pathways. Its study may contribute to understanding disease mechanisms and therapeutic targeting. Current research remains exploratory, emphasizing the need for further characterization of its cellular roles and disease associations.
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