| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC56 |
| Uniprot No | Q8IYG6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-542aa |
| 活性数据 | MDLGWDRSRGPRRSTSSVRVRELSWQGLHNPCPQSKGPGSQRDRLGEQLVEEYLSPARLQALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSHPSPVPT |
| 分子量 | 85.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于人LRRC56蛋白(富含亮氨酸重复序列蛋白56)的研究目前较为有限，以下为基于相关领域研究的推测性文献示例(实际文献可能需要通过学术数据库检索验证)：
1. **作者**: Zhang et al.
**文献名称**: "LRRC56 interacts with microtubule transport complexes in ciliary function"
**摘要**: 研究揭示了LRRC56通过与纤毛内的微管马达蛋白(如动力蛋白)相互作用，调控纤毛内转运过程，可能影响信号传导与细胞运动。
2. **作者**: Lee et al.
**文献名称**: "Structural analysis of human LRRC56 reveals a conserved leucine-rich repeat motif"
**摘要**: 通过X射线晶体学解析了LRRC56的晶体结构，发现其典型的LRR结构域可能参与蛋白质相互作用，为功能机制研究提供结构基础。
3. **作者**: Wang & Smith
**文献名称**: "LRRC56 deficiency disrupts spermatogenesis in mouse models"
**摘要**: 在小鼠模型中，LRRC56基因敲除导致精子形成异常，表明其在雄性生殖细胞发育中可能起关键作用。
4. **作者**: Tanaka et al.
**文献名称**: "Proteomic identification of LRRC56 as a centrosomal protein involved in cell cycle progression"
**摘要**: 蛋白质组学分析发现LRRC56定位于中心体，可能通过调控有丝分裂进程影响细胞周期。
**注意**：以上文献为假设性概括，实际研究中需以具体数据库(如PubMed、Google Scholar)检索关键词“LRRC56”或“leucine-rich repeat-containing protein 56”获取真实文献。
Recombinant human LRRC56 protein is a engineered version of the leucine-rich repeat-containing protein 56. a member of the LRRC family characterized by tandem leucine-rich repeat (LRR) motifs that mediate protein-protein interactions. LRRC56 is encoded by the *LRRC56* gene and is implicated in microtubule-related processes, particularly in cilia and flagella function. Studies suggest its involvement in regulating ciliary motility and spermatogenesis, with potential roles in intracellular trafficking and signaling pathways. Dysregulation of LRRC56 has been tentatively linked to ciliopathies and reproductive disorders.
The recombinant form is typically produced using heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable high-purity, scalable yields for research. It serves as a critical tool for structural studies (e.g., crystallography or cryo-EM) to map interaction domains and mechanistic insights. Functional assays using recombinant LRRC56 have explored its binding partners, such as tubulin or motor proteins, and its modulation of microtubule dynamics.
Current research focuses on elucidating its role in ciliary beating mechanics and its potential as a biomarker or therapeutic target. Advances in recombinant technology facilitate further exploration of LRRC56's pathophysiological relevance, bridging gaps in understanding cellular motility disorders.
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