| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC55 |
| Uniprot No | Q6ZSA7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-341aa |
| 活性数据 | MLRSPTFTDAGPRCSCLPVSQTLDSMDTVLMGSLQHCCCLLPKMGDTWAQLPWPGPPHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI |
| 分子量 | 64 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC55蛋白研究的参考文献范例(注意：以下为虚拟示例，实际文献需通过学术数据库检索获取)：
1. **文献名称**: *Structural insights into human LRRC55 protein through recombinant expression*
**作者**: Zhang, Q. et al.
**摘要**: 本研究通过大肠杆菌重组表达系统成功制备了人源LRRC55蛋白，解析了其晶体结构，揭示其富含亮氨酸重复结构域(LRR)的折叠模式及潜在配体结合位点，为功能研究奠定基础。
2. **文献名称**: *LRRC55 modulates neuronal signaling via interaction with synaptic receptors*
**作者**: Tanaka, S. et al.
**摘要**: 研究发现重组人LRRC55蛋白在海马神经元中通过与AMPA受体复合物相互作用调节突触传递，提示其在神经可塑性中的潜在作用，并开发了基于哺乳动物细胞系的蛋白纯化策略。
3. **文献名称**: *LRRC55 as a novel biomarker in renal cell carcinoma: recombinant protein-based analysis*
**作者**: Chen, L. et al.
**摘要**: 利用HEK293细胞表达的重组LRRC55蛋白，证明其在肾癌细胞中异常高表达，通过ELISA检测患者血清水平显示其与肿瘤分期相关，提示其作为诊断标志物的可能性。
4. **文献名称**: *Functional screening of LRRC family proteins identifies LRRC55 as a regulator of TGF-β signaling*
**作者**: Park, J. et al.
**摘要**: 系统性研究LRRC家族蛋白功能，发现重组人LRRC55可抑制TGF-β信号通路，并通过体外实验证实其与Smad7蛋白的互作机制，为靶向治疗提供新思路。
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**提示**：以上为模拟案例，实际文献需通过PubMed、Web of Science等平台检索关键词(如“recombinant LRRC55”或“LRRC55 function”)获取。建议结合该蛋白的已知功能(如离子通道调控、神经或癌症相关通路)扩大检索范围。
Recombinant human LRRC55 (Leucine-Rich Repeat-Containing protein 55) is a engineered form of the LRRC55 protein, a member of the leucine-rich repeat (LRR) superfamily characterized by tandem repeats of 20-30 amino acid motifs rich in leucine. These structural domains enable LRRC55 to participate in protein-protein interactions, often critical for cellular signaling, adhesion, or receptor-ligand recognition. The native LRRC55 is a transmembrane or secreted protein, depending on isoform variations, and is predominantly expressed in neural tissues, suggesting roles in neurodevelopment, synaptic plasticity, or ion channel regulation. Its exact physiological functions remain under investigation, though studies link it to potassium channel modulation and potential involvement in neurological disorders.
Recombinant production typically involves heterologous expression systems (e.g., mammalian cells, E. coli) to generate soluble, purified protein tagged for detection (e.g., His-tag). This allows researchers to study LRRC55's structure-function relationships, map binding partners, and explore its interactions with signaling pathways. Applications include antibody development, mechanistic studies in neuronal networks, and drug discovery targeting LRRC55-associated diseases. Emerging research also explores its role in cancer progression and immune regulation, highlighting its potential as a therapeutic target or biomarker. Further studies aim to clarify its precise biological significance and translational relevance.
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