| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KLF11 |
| Uniprot No | O14901 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-512aa |
| 活性数据 | MHTPDFAGPDDARAVDIMDICESILERKRHDSERSTCSILEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAESPGSPLVSMPASA |
| 分子量 | 81.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人KLF11蛋白相关的3-4篇模拟参考文献示例(非真实文献，供参考)：
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1. **文献名称**：*"KLF11 regulates cell cycle progression by repressing cyclin D1 transcription"*
**作者**：Smith JD et al.
**摘要**：研究报道重组人KLF11蛋白通过结合Cyclin D1启动子区域抑制其转录活性，调控细胞周期G1/S期转换，揭示其在肿瘤抑制中的潜在机制。
2. **文献名称**：*"Recombinant human KLF11 suppresses epithelial-mesenchymal transition in pancreatic cancer via TGF-β/Smad signaling"*
**作者**：Chen L et al.
**摘要**：体外实验表明，重组KLF11蛋白通过干扰Smad蛋白与TGF-β通路协同作用，抑制胰腺癌细胞EMT过程，提示其作为癌症治疗靶点的潜力。
3. **文献名称**：*"KLF11 modulates insulin gene expression and glucose homeostasis in type 2 diabetes models"*
**作者**：Zhang R et al.
**摘要**：在小鼠模型中，重组KLF11蛋白被证明通过激活胰岛素启动子活性增强β细胞功能，改善高血糖症状，为糖尿病治疗提供新方向。
4. **文献名称**：*"Structural and functional characterization of recombinant human KLF11 in DNA binding assays"*
**作者**：Lee H et al.
**摘要**：通过体外DNA结合实验解析KLF11蛋白的锌指结构域，证实其特异性结合GC盒序列的能力，为后续疾病相关基因调控研究奠定基础。
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注：以上文献信息为虚构示例，实际研究中请通过PubMed或Web of Science检索真实文献。
Recombinant human KLF11 (Krüppel-like factor 11) protein is a synthetic form of the transcription factor encoded by the *KLF11* gene, belonging to the SP1-like/KLF family. KLF11 is characterized by three conserved C-terminal zinc finger motifs that mediate DNA binding, and it functions as a transcriptional regulator, either activating or repressing target genes depending on cellular context. It plays critical roles in cellular processes, including differentiation, proliferation, apoptosis, and metabolic homeostasis. KLF11 is widely expressed in tissues such as the pancreas, brain, and gastrointestinal tract. Research links it to diseases like diabetes, cancer, and neurodegenerative disorders. For instance, it modulates insulin sensitivity and β-cell function in diabetes, suppresses tumor growth by interacting with TGF-β signaling pathways, and is implicated in neuroprotection. Recombinant KLF11 protein, produced via bacterial or mammalian expression systems, retains functional activity and is utilized for *in vitro* studies to dissect molecular mechanisms, screen therapeutic compounds, or analyze DNA-protein interactions. Its applications extend to understanding epigenetic regulation, disease pathology, and drug development. Quality control ensures high purity and bioactivity, making it a valuable tool in biomedical research. Current studies focus on its therapeutic potential in precision medicine, particularly for metabolic and age-related diseases.
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