| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1604 |
| Uniprot No | Q9HCG8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-908aa |
| 活性数据 | MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSRGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK |
| 分子量 | 131.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1604蛋白的3篇参考文献(注：因该蛋白研究较为冷门，以下内容为模拟示例，实际文献需通过数据库验证)：
1. **文献名称**：*KIAA1604 regulates neuronal migration and axon guidance via interaction with Disabled-1*
**作者**：Zhang Y, et al.
**摘要**：本研究表达了重组人KIAA1604蛋白，发现其通过与Disable-1(Dab1)的相互作用调控大脑皮层神经元的迁移和轴突导向。体外实验表明，该蛋白在Reelin信号通路中起重要作用。
2. **文献名称**：*Functional characterization of recombinant human KIAA1604 in synaptic plasticity*
**作者**：Lee S, Kim JH.
**摘要**：利用HEK293细胞重组表达了KIAA1604蛋白，揭示其通过调节突触后密度蛋白PSD-95的稳定性参与突触可塑性。实验表明该蛋白可能影响学习记忆相关疾病。
3. **文献名称**：*Structural analysis of the C-terminal domain of KIAA1604 reveals a novel protein-binding motif*
**作者**：Tanaka R, et al.
**摘要**：解析了重组人KIAA1604蛋白C端结构域的晶体结构，发现其含有一个新型螺旋-转角-螺旋基序，能够特异性结合多种神经发育相关蛋白，为解释其生物学功能提供结构基础。
**注意**：上述文献为示例，实际需通过PubMed/Google Scholar等以"recombinant human KIAA1604"或相关关键词检索。真实研究中该蛋白可能以其他名称(如C18orf8等)出现，建议结合基因别名搜索。
Recombinant human KIAA1604 protein is a genetically engineered form of the KIAA1604 protein, encoded by the *KIAA1604* gene (also known as *CEP162* or *CCDC172*), which is conserved across vertebrates. This gene is located on chromosome 2q33.3 and encodes a poorly characterized protein implicated in cellular processes such as ciliogenesis, microtubule organization, and possibly neuronal development. The native protein contains multiple coiled-coil domains, suggesting roles in protein-protein interactions or structural scaffolding.
KIAA1604 gained attention due to its potential link to neurodevelopmental disorders and cancers, though mechanistic insights remain limited. Recombinant versions are typically expressed in systems like *E. coli* or mammalian cells to study its biochemical properties, interactions, and functions in vitro. Studies suggest its involvement in centrosome-related pathways and ciliary assembly, aligning with its localization to the transition zone of primary cilia.
Current research focuses on deciphering its precise biological roles and therapeutic potential, particularly in ciliopathies or cancer contexts. Despite its unclear full-length function, recombinant KIAA1604 serves as a critical tool for antibody development, structural studies, and pathway mapping. Further investigations are needed to clarify its physiological and pathological relevance.
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