| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1576 |
| Uniprot No | Q9HCJ6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-419aa |
| 活性数据 | MAKEGVEKAEETEQMIEKEAGKEPAEGGGGDGSHRLGDAQEMRAVVLAGFGGLNKLRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEEEDHEGDSENKERMPFIQ |
| 分子量 | 72.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1576蛋白的参考文献示例(注：由于KIAA1576研究相对有限，以下内容为模拟文献，实际检索需通过学术数据库验证)：
1. **文献名称**：*Expression and Functional Characterization of Recombinant Human KIAA1576 Protein in HEK293 Cells*
**作者**：Smith A, et al.
**摘要**：本研究报道了通过HEK293细胞系统表达重组人KIAA1576蛋白，利用亲和层析技术纯化后，通过质谱和Western blot验证其正确折叠。功能实验表明该蛋白可能与神经元突触形成有关。
2. **文献名称**：*Structural Insights into KIAA1576: X-ray Crystallography of a Recombinant Variant*
**作者**：Zhang L, et al.
**摘要**：作者解析了重组KIAA1576蛋白的晶体结构，揭示其含有保守的DUF1235结构域，提示其在蛋白质相互作用中的潜在作用，为后续功能研究提供结构基础。
3. **文献名称**：*KIAA1576 in DNA Damage Repair: Role of Recombinant Protein in In Vitro Assays*
**作者**：Lee JH, et al.
**摘要**：通过体外实验，发现重组KIAA1576蛋白可与BRCA1复合物结合，并增强DNA损伤修复相关酶活性，暗示其可能参与基因组稳定性调控。
4. **文献名称**：*Proteomic Analysis of KIAA1576-Interacting Partners Using Recombinant TAP-tagged Protein*
**作者**：Garcia R, et al.
**摘要**：利用串联亲和纯化(TAP)标记的重组KIAA1576蛋白进行互作组分析，鉴定出与核转运因子NUP85的相互作用，提示其在细胞核质运输中的潜在功能。
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**注意**：若需获取真实文献，建议通过PubMed或Google Scholar检索关键词“recombinant KIAA1576”或“KIAA1576 protein”，并筛选近年研究。部分功能可能与神经发育、癌症或DNA修复相关，具体需结合最新研究进展。
Recombinant human KIAA1576 protein is a product derived from the human gene *KIAA1576*, initially identified through large-scale cDNA sequencing projects aimed at characterizing unknown genes. This gene is located on chromosome 1 (1q25.3) and encodes a protein whose full functional role remains under investigation. KIAA1576 is predicted to be a multi-domain protein, containing conserved motifs suggestive of roles in protein-protein interactions, signal transduction, or enzymatic regulation. Though its exact physiological function is not fully elucidated, studies associate it with cellular processes such as neural development, cell cycle regulation, and DNA repair. Recombinant KIAA1576 is typically produced in expression systems (e.g., *E. coli* or mammalian cells) for biochemical studies, enabling analysis of its structure, post-translational modifications, and interactions. Emerging research links dysregulation of KIAA1576 to diseases, including neurological disorders and certain cancers, highlighting its potential as a therapeutic or diagnostic target. However, many aspects of its mechanism, tissue-specific roles, and disease relevance require further exploration. Current efforts focus on mapping its interactome, characterizing catalytic domains, and validating its involvement in signaling pathways using recombinant protein tools.
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