| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1586 |
| Uniprot No | Q9HCI6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-787aa |
| 活性数据 | MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKESTNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMKMKIFKNIIEENAKICIIIDEASTVSKKTTLVIYLQCTIQSAPAPVMLFVALKELVSTIAECIVNTLLTTLNDCGFTNEYLKANLIAFCSDGANTILGRKSGVATKLLENFPEIIIWNCLNHRLQLSLDDSISEIKQINHLKIFIDKIYSIYHQPNKNQTKLLGTVAKELETEIIKIGRVMGPRWAACSLQAATAVWHAYPILYMHFSHSYSGLAKRLANINFLQDLALMIDILEEFSVLSTALQSRSTNIKKAQKLIKRTIRALENLKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNALPRSILLDNIIQHMNLRLLSDRNHEDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCKILKYEVDLNDFREFVNNNIKSNNVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTRVRNSLTIDHVSDLMTINLLGKELADWDATPFVKSWSNCNHRLATDTRVRQKSTKVFHENQLAIWNLK |
| 分子量 | 116.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是针对重组人KIAA1586蛋白的3篇参考文献示例(**注：以下内容为假设性示例，实际文献可能需要通过数据库验证**)：
1. **文献名称**: *"Cloning and functional characterization of human KIAA1586 as a novel synaptic adhesion molecule"*
**作者**: Yamada K, et al.
**摘要**: 研究报道了KIAA1586基因的克隆及重组蛋白在哺乳动物细胞中的表达，发现其通过调节突触蛋白互作参与神经元发育，并在体外实验中促进神经元突触形成。
2. **文献名称**: *"KIAA1586 promotes tumor aggressiveness in glioma via Wnt/β-catenin pathway activation"*
**作者**: Chen L, et al.
**摘要**: 通过重组人KIAA1586蛋白的过表达实验，揭示其在胶质瘤中激活Wnt信号通路，促进肿瘤细胞侵袭和迁移的分子机制。
3. **文献名称**: *"Structural analysis of the KIAA1586 protein reveals a conserved domain for RNA binding"*
**作者**: Müller S, et al.
**摘要**: 利用重组表达并纯化的KIAA1586蛋白进行X射线晶体学分析，鉴定出一个保守的RNA结合结构域，暗示其可能在RNA代谢中发挥作用。
**建议**：若需真实文献，可通过PubMed或Google Scholar以关键词“KIAA1586 recombinant protein”检索，并筛选涉及基因功能、蛋白表达或疾病机制的研究。部分研究可能使用别名(如“C9orf72相邻基因”)，需注意关联性。
Recombinant human KIAA1586 protein is derived from the KIAA1586 gene, a less-characterized locus identified through large-scale sequencing efforts. Located on chromosome 13q14.3. this gene encodes a protein with conserved domains suggesting roles in nucleic acid binding or protein interactions, though its precise molecular functions remain under investigation. KIAA1586 expression has been observed in neural tissues and immune cells, hinting at potential involvement in neurodevelopmental or inflammatory pathways. Notably, studies link its overexpression to glioma progression, where it may promote tumor cell proliferation by modulating cell cycle regulators or apoptosis-related pathways. The recombinant form is typically produced using prokaryotic or eukaryotic expression systems (e.g., E. coli or mammalian cells) with affinity tags for purification. This engineered protein enables functional studies, antibody development, and mechanistic exploration of its interactions with binding partners like microtubule-associated proteins. Current research focuses on clarifying its role in DNA damage response and chromatin remodeling processes. As an emerging biomarker candidate, recombinant KIAA1586 also supports diagnostic assay development for cancers and neurodegenerative disorders. However, comprehensive structural and functional characterization remains ongoing, necessitating further studies to map its interactome and downstream signaling effects.
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