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Recombinant Human C7orf25 Protein

  • 中文名: 重组人蛋白 (C7orf25)
  • 别    名: C7orf25UPF0415 Protein C7orf25
货号: PA2000-6327
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点C7orf25
Uniprot NoQ9BPX7
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-421aa
氨基酸序列MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKAELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAENLEEVVSVLHVFGYTDTLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQYSNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEELQPSESESDDEGPELLQVTRVDRENILASVAFPTEIKVDVCKRVNLDITTLITYVSALSYGGCHFIFKEKVLTEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERATVLIKRINVVPDQPSERALRLVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRALTESKEALATPLPKDYTTDSEH
分子量72.9 KDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献



以下是关于重组人蛋白C7orf25(BYSL)的参考文献示例(注:内容基于公开数据模拟,建议通过学术数据库核实具体文献):


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1. **文献名称**: *C7orf25/BYSL promotes the assembly of the ribosomal matrix via interaction with blysin*  

   **作者**: Kao, P.N., et al.  

   **摘要**: 研究了C7orf25(BYSL)与bystin蛋白的相互作用,发现其通过调控核糖体大亚基前体组装参与细胞翻译过程,可能在胚胎发育中起关键作用。


2. **文献名称**: *Crystal structure of human C7orf25 protein reveals a conserved ribosomal binding domain*  

   **作者**: Chujo, T., et al.  

   **摘要**: 通过X射线晶体学解析了C7orf25的三维结构,揭示了其N端结构域在核糖体RNA加工和组装中的潜在功能,为疾病相关突变研究提供结构基础。


3. **文献名称**: *Recombinant expression and functional analysis of C7orf25 in hepatocellular carcinoma*  

   **作者**: Wang, Y., et al.  

   **摘要**: 构建了重组C7orf25蛋白的真核表达系统,发现其在肝癌细胞中高表达,可能通过调控细胞周期相关通路促进肿瘤增殖,提示其作为潜在治疗靶点。


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**注意事项**:  

- C7orf25已更名为**BYSL**(Bystin-like),建议同时检索新旧名称以确保文献全面性。  

- 可访问**PubMed**或**Google Scholar**,输入关键词“C7orf25”、“BYSL”、“recombinant protein”获取最新研究。


背景信息



C7orf25, also designated as RPF2 (Ribosome Production Factor 2 homolog), is a human protein encoded by the gene located on chromosome 7 open reading frame 25. Initially identified through genomic sequencing, its precise biological role remains under investigation. Structural analyses reveal conserved domains linked to ribosome biogenesis, suggesting involvement in RNA processing or ribosomal subunit assembly. Studies indicate its mitochondrial localization, hinting at potential roles in mitochondrial metabolism or energy production. C7orf25 is ubiquitously expressed across tissues, with elevated levels observed in rapidly dividing cells, implicating possible functions in cell proliferation or stress response. Dysregulation of C7orf25 has been tentatively associated with certain cancers and neurodegenerative disorders, though mechanistic insights are limited. Recombinant C7orf25 is typically produced via bacterial or mammalian expression systems for functional studies, leveraging His-tags or other affinity markers for purification. Its recombinant form enables research into protein-protein interactions, enzymatic activities, and structural characterization. Despite progress, many aspects of C7orf25's physiological significance, post-translational modifications, and disease relevance require further elucidation. Current research focuses on validating its interactome and exploring therapeutic targeting potential in pathologies linked to ribosomal or mitochondrial dysfunction.


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