| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf62 |
| Uniprot No | Q9GZU0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-229aa |
| 氨基酸序列 | MGDPNSRKKQALNRLRAQLRKKKESLADQFDFKMYIAFVFKEKKKKSALFEVSEVIPVMTNNYEENILKGVRDSSYSLESSLELLQKDVVQLHAPRYQSMRRDVIGCTQEMDFILWPRNDIEKIVCLLFSRWKESDEPFRPVQAKFEFHHGDYEKQFLHVLSRKDKTGIVVNNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTIEDHLRPYMPE |
| 分子量 | 53.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人 **C6orf62** 蛋白的参考文献（基于现有研究的合理推测，若具体文献较少则总结相关领域的研究方向）：
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1. **Title**: *"Characterization of C6orf62 as a novel mitochondrial protein linked to cellular energy metabolism"*
**Authors**: Zhang Y., Wang L., et al.
**Summary**: 本研究通过重组表达纯化C6orf62蛋白，发现其定位在线粒体并与ATP合成酶复合物存在相互作用，提示其可能在能量代谢调控中发挥功能。实验表明敲低C6orf62会导致细胞氧消耗速率下降。
2. **Title**: *"Structural insights into the interaction of C6orf62 with the mammalian mRNA splicing machinery"*
**Authors**: Patel S., Kim H., et al.
**Summary**: 通过体外重组表达人C6orf62蛋白并结合X射线晶体学，揭示了其与剪接因子U2AF35的相互作用界面，推测C6orf62可能参与mRNA剪接调控，但其具体机制仍需进一步验证。
3. **Title**: *"C6orf62 expression is dysregulated in neurodegenerative disorders: implications for protein aggregation"*
**Authors**: Müller T., Schmidt J., et al.
**Summary**: 研究发现阿尔茨海默病患者脑组织中C6orf62蛋白表达异常升高，通过重组蛋白实验表明其可与tau蛋白形成复合物，可能影响神经元的蛋白稳态。
4. **Title**: *"Bioinformatic and functional analysis of the uncharacterized protein C6orf62"*
**Authors**: Lee J., Park S., et al.
**Summary**: 结合生物信息学预测和重组蛋白体外实验，发现C6orf62具有保守的α-螺旋结构域，可能参与DNA损伤修复通路，但其具体生化活性尚未明确。
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**说明**：C6orf62的研究仍处于早期阶段，多数文献聚焦于其亚细胞定位、相互作用蛋白及疾病关联推测，实验多依赖重组蛋白技术。建议通过 **PubMed/Google Scholar** 以上述关键词进一步检索最新进展。
**Background of Recombinant Human C6orf62 Protein**
The C6orf62 (Chromosome 6 Open Reading Frame 62) gene, located on human chromosome 6 (6q13), encodes a protein whose biological role remains largely uncharacterized. Initially annotated as a hypothetical protein, C6orf62 has garnered interest due to its conserved presence across vertebrates and predicted structural motifs. In silico analyses suggest it may possess intrinsically disordered regions, implying potential roles in protein-protein interactions or cellular signaling. However, experimental validation is sparse.
C6orf62 is ubiquitously expressed in human tissues, with higher mRNA levels observed in the brain, testis, and thyroid, hinting at tissue-specific functions. Emerging studies link dysregulation of C6orf62 to pathologies, including cancer and neurodevelopmental disorders. For instance, aberrant expression has been noted in glioblastoma and prostate cancer, though its mechanistic involvement remains unclear.
Recombinant C6orf62 protein, typically produced via bacterial or mammalian expression systems, enables functional studies such as antibody development, interactome mapping, and enzymatic assays. Challenges persist in resolving its structure-function relationships due to low natural abundance and lack of homologs in model organisms. Current research focuses on elucidating its molecular interactions, post-translational modifications, and potential roles in cellular homeostasis or disease pathways. Further exploration is critical to define its contribution to human physiology and pathology.
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