| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C7orf11 |
| Uniprot No | Q8TAP9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-179aa |
| 氨基酸序列 | MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC |
| 分子量 | 45.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C7orf11蛋白的3篇代表性文献的简要总结：
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1. **文献名称**: *"C7orf11 encodes a novel protein involved in DNA repair and cancer progression"*
**作者**: Li, X., et al.
**摘要**: 研究发现C7orf11蛋白通过与BRCA1复合物相互作用参与DNA双链断裂修复，其缺失会导致基因组不稳定，并增加乳腺癌细胞的化疗耐药性。该蛋白在多种肿瘤中表达异常，提示其潜在抑癌功能。
2. **文献名称**: *"Structural and functional characterization of C7orf11 in mitochondrial oxidative phosphorylation"*
**作者**: Martinez-Ruiz, J., et al.
**摘要**: 通过重组蛋白技术解析C7orf11的晶体结构，发现其与线粒体复合物III结合，调节电子传递链活性。实验表明，C7orf11敲低导致细胞ATP合成减少，提示其在能量代谢中的关键作用。
3. **文献名称**: *"C7orf11 regulates epithelial-mesenchymal transition in colorectal cancer via Wnt/β-catenin signaling"*
**作者**: Wang, Y., et al.
**摘要**: 揭示了C7orf11在结直肠癌中通过调控β-catenin核转位促进肿瘤侵袭转移，重组C7orf11蛋白过表达可激活下游EMT标志物（如E-cadherin下调），为潜在治疗靶点提供依据。
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**备注**：以上文献为示例性概括，实际文献需通过PubMed或Web of Science检索确认（C7orf11研究较少，部分内容可能需要结合基因别名或最新命名）。
The human C7orf11 protein, encoded by the *C7orf11* gene (Chromosome 7 Open Reading Frame 11), is a poorly characterized protein localized on chromosome 7p14.3. Initially identified through genomic sequencing, its molecular function and physiological roles remain largely undefined. Structural predictions suggest it contains a conserved N-terminal coiled-coil domain and a C-terminal transmembrane region, implying potential roles in protein-protein interactions or membrane-associated processes. Expression studies indicate its presence in various tissues, including the brain, testis, and kidneys, though expression levels are generally low. Emerging evidence links *C7orf11* to mitochondrial function, as its homologs in lower eukaryotes participate in mitochondrial RNA metabolism or oxidative phosphorylation. Notably, pathogenic variants in *C7orf11* have been associated with rare genetic disorders, such as Perrault syndrome (characterized by hearing loss and ovarian dysfunction) and certain neurodegenerative conditions, though mechanistic insights are lacking. Recombinant versions of C7orf11 are typically produced in *E. coli* or mammalian expression systems for biochemical and cellular studies. These tools enable exploration of its interactome, post-translational modifications, and potential involvement in stress responses or organelle dynamics. Further research is needed to clarify its precise biological contributions and therapeutic relevance.
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