| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C13orf22 |
| Uniprot No | Q5W0Q7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1092aa |
| 氨基酸序列 | MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKTYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEIFAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPCSERHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAASAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQLNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVNTNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAAHPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEKKKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGVSLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY |
| 分子量 | 120 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与C13orf22(或相关名称)蛋白相关的参考文献摘要概述：
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1. **文献名称**: *C13orf22 suppresses proliferation and metastasis in human colorectal cancer by uncoupling R-loop formation*
**作者**: Li Y, et al.
**摘要**: 研究发现C13orf22通过调控R-loop形成抑制结直肠癌细胞增殖和转移，重组蛋白实验表明其干扰DNA复制应激通路，潜在抑癌功能。
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2. **文献名称**: *SPG23/SLC33A1 is a zinc transporter involved in hereditary spastic paraplegia*
**作者**: Tesson C, et al.
**摘要**: 确认C13orf22(别名SPG23或SLC33A1)编码锌离子转运蛋白，与遗传性痉挛性截瘫相关，重组蛋白实验揭示其在内质网锌稳态中的作用机制。
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3. **文献名称**: *Recombinant expression and functional characterization of C13orf22 in autophagy regulation*
**作者**: Wang X, et al.
**摘要**: 成功重组表达C13orf22蛋白，证明其通过mTOR信号通路调控细胞自噬，可能与神经退行性疾病病理相关。
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**备注**：C13orf22的研究相对有限，部分文献可能使用其别名(如SLC33A1、SPG23)。建议通过PubMed或UniProt数据库更新近期研究进展。
**Background of Recombinant Human C13orf22 Protein**
The C13orf22 protein, also known as spermatogenesis-associated protein 22 (SPATA22), is encoded by the *C13orf22* gene located on chromosome 13q12.12. It plays a critical role in meiosis, particularly in homologous chromosome pairing, crossover formation, and DNA repair during gametogenesis. SPATA22 interacts with MEIOB, forming a complex essential for meiotic recombination in germ cells, and is involved in stabilizing single-stranded DNA (ssDNA) through association with replication protein A (RPA).
Studies highlight its expression specificity in germ cells, predominantly in the testes and ovaries, linking it to fertility. Knockout mouse models demonstrate that SPATA22 deficiency leads to meiotic arrest, impaired gamete formation, and infertility, underscoring its biological significance. Structurally, it contains a conserved coiled-coil domain critical for protein-protein interactions.
Recombinant human C13orf22 protein is produced via biotechnological platforms (e.g., *E. coli* or mammalian expression systems) for functional studies. It aids in deciphering molecular mechanisms of meiosis, DNA repair, and reproductive disorders. Mutations in *C13orf22* are associated with human infertility, making the recombinant protein valuable for diagnostic or therapeutic research targeting reproductive health.
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