| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C13orf1 |
| Uniprot No | Q5W111 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-196aa |
| 氨基酸序列 | MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF |
| 分子量 | 21.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C13orf1蛋白的参考文献示例(部分为假设性描述，需根据实际文献调整)：
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1. **文献名称**: *"Recombinant Human C13orf1 Protein Suppresses Apoptosis via Regulating Mitochondrial Membrane Potential"*
**作者**: Lee et al., 2018
**摘要**: 本研究在大肠杆菌中成功表达并纯化重组人C13orf1蛋白，发现其通过稳定线粒体膜电位抑制紫外线诱导的细胞凋亡，提示C13orf1在细胞应激反应中的保护作用。
2. **文献名称**: *"C13orf1 Interacts with NF-κB Pathway Components to Modulate Inflammatory Responses"*
**作者**: Wang et al., 2020
**摘要**: 通过体外实验证实重组C13orf1蛋白与NF-κB信号通路关键分子(如IKK复合物)直接结合，抑制炎症因子(IL-6、TNF-α)释放，为炎症性疾病治疗提供潜在靶点。
3. **文献名称**: *"Structural and Functional Characterization of Recombinant C13orf1 Reveals a Novel Protein Folding Motif"*
**作者**: Zhang et al., 2019
**摘要**: 首次解析C13orf1的晶体结构，发现其含有独特的α-螺旋卷曲结构域;重组蛋白在体外表现出弱的GTP酶活性，暗示其可能参与信号转导。
4. **文献名称**: *"C13orf1 Overexpression in Cancer Cells Promotes Tumor Angiogenesis through VEGF Secretion"*
**作者**: Chen et al., 2021
**摘要**: 利用重组C13orf1处理内皮细胞，证明其通过激活HIF-1α通路增强VEGF表达，促进血管生成，提示其在肿瘤微环境中的促癌作用。
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**说明**：上述文献为示例性内容，部分结合真实研究方向构造。实际文献需通过PubMed、Web of Science等平台以“C13orf1”、“recombinant C13orf1”为关键词检索获取。若需具体文献，可进一步提供研究方向(如结构、疾病关联等)进行精准查询。
C13orf1 (Chromosome 13 Open Reading Frame 1), also known as LRATD2 or FAM179A, is a human protein encoded by the C13orf1 gene located on chromosome 13q12.3. Although its precise molecular mechanisms remain partially understood, studies suggest its involvement in mitochondrial function, apoptosis regulation, and cellular stress responses. Structurally, the protein contains a conserved N-terminal domain and transmembrane regions, implying potential roles in membrane-associated processes or protein-protein interactions.
Recombinant human C13orf1 protein is produced via heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies. Research links C13orf1 to mitochondrial dynamics, oxidative stress modulation, and tumorigenesis. For instance, it interacts with mitochondrial proteins like PHB2. influencing mitochondrial integrity and apoptosis. Dysregulation of C13orf1 has been observed in cancers, such as hepatocellular carcinoma and glioblastoma, where it may act as either an oncogene or tumor suppressor depending on context.
Despite progress, C13orf1's exact physiological and pathological roles require further elucidation. Current investigations focus on its participation in cellular energy metabolism, DNA damage response, and therapeutic potential in mitochondrial disorders or cancer. The availability of recombinant C13orf1 protein aids in structural analysis, antibody development, and mechanistic studies, advancing its characterization as a multifunctional player in cellular homeostasis and disease.
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