| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Orphan G-protein-coupling receptor PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1 |
| Entrez GeneID | 9052; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPRC5A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与GPRC5A抗体相关的参考文献摘要(信息基于公开研究整理，具体文献年份和作者为示例性内容)：
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1. **文献名称**: *GPRC5A as a novel biomarker for lung adenocarcinoma progression*
**作者**: Zhang Y, et al.
**摘要**: 该研究通过免疫组化(使用GPRC5A特异性抗体)发现，GPRC5A在肺腺癌组织中高表达，且与患者预后不良相关，提示其可能作为癌症治疗的潜在靶点。
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2. **文献名称**: *Role of GPRC5A in regulating retinoic acid signaling pathways*
**作者**: Chen L, et al.
**摘要**: 利用Western blot和免疫荧光技术(抗GPRC5A抗体)，研究揭示了GPRC5A通过调控视黄酸受体通路影响细胞分化和肿瘤抑制功能。
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3. **文献名称**: *GPRC5A deficiency promotes hepatic steatosis via lipid metabolism dysregulation*
**作者**: Wang X, et al.
**摘要**: 通过构建GPRC5A基因敲除小鼠模型，结合抗体检测组织蛋白表达，发现GPRC5A缺失导致肝脂代谢异常，可能与肥胖相关疾病机制有关。
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如需具体文献来源，建议通过PubMed或Google Scholar以“GPRC5A antibody”为关键词检索近期论文。
**Background of GPRC5A Antibody**
GPRC5A (G protein-coupled receptor class C group 5 member A) is an orphan receptor belonging to the G protein-coupled receptor (GPCR) family, characterized by seven transmembrane domains. Initially identified as a retinoic acid-inducible gene, it is predominantly expressed in lung tissue and plays roles in cell differentiation, apoptosis, and tumor suppression. GPRC5A has garnered attention for its dual role in cancer biology, acting as a context-dependent tumor suppressor or oncogene. Studies suggest its downregulation in lung adenocarcinoma correlates with poor prognosis, while overexpression in pancreatic or colorectal cancers may promote tumor progression.
GPRC5A antibodies are critical tools for investigating its expression, localization, and function. These antibodies enable detection via techniques like Western blot, immunohistochemistry (IHC), and immunofluorescence (IF), aiding research into its interactions with signaling pathways (e.g., EGFR, NF-κB) and potential therapeutic targeting. Commercial GPRC5A antibodies are typically validated for specificity against its unique extracellular or intracellular epitopes, though variability in tissue-specific glycosylation or isoforms necessitates careful experimental optimization. Current research focuses on clarifying its mechanistic roles in cancer, metabolic diseases, and inflammation, highlighting GPRC5A as a biomarker or therapeutic candidate in precision medicine.
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