| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6 |
| Entrez GeneID | 2559; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GABRA6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于GABRA6抗体的3篇示例文献(内容为合理虚构，建议通过学术数据库核实)：
1. **文献名称**: "GABRA6 expression in cerebellar development: Insights from immunohistochemical analysis"
**作者**: Smith J, et al.
**摘要**: 本研究利用GABRA6特异性抗体，通过免疫组化技术揭示了GABRA6在小鼠小脑发育过程中的动态表达模式，证实其在颗粒细胞分化中的关键作用，并与运动协调功能相关。
2. **文献名称**: "Altered GABRA6 subunit levels in temporal lobe epilepsy: A postmortem study"
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光分析，发现癫痫患者海马组织中GABRA6蛋白表达显著降低，提示该受体亚基缺陷可能参与癫痫发生中GABA能信号通路异常。
3. **文献名称**: "Pharmacological profiling of GABRA6-specific antibodies in benzodiazepine sensitivity assays"
**作者**: Rodriguez M, et al.
**摘要**: 研究验证了两种商业GABRA6抗体的特异性，并证明其在体外模型中可阻断苯二氮䓬类药物对α6βγ2受体亚型的变构调节作用，为药物靶向研究提供工具。
4. **文献名称**: "GABRA6 knockout validation via antibody-based protein localization in murine models"
**作者**: Tanaka K, et al.
**摘要**: 通过对比野生型与GABRA6基因敲除小鼠的小脑切片，确认所用抗体可特异性识别GABRA6蛋白，为受体亚型功能研究提供可靠检测方法。
**注意**：以上文献信息为示例性质，实际引用请通过PubMed、Google Scholar等平台检索真实文献。
The GABRA6 antibody is a specialized tool used to detect and study the gamma-aminobutyric acid type A (GABAₐ) receptor subunit alpha-6 (GABRA6), a critical component of inhibitory neurotransmission in the central nervous system. GABAₐ receptors are ligand-gated chloride ion channels that mediate fast synaptic inhibition, playing essential roles in regulating neuronal excitability, anxiety, and motor control. The α6 subunit, encoded by the *GABRA6* gene, is predominantly expressed in cerebellar granule cells, where it forms receptors with β and γ subunits. These receptors exhibit high sensitivity to GABA and are implicated in modulating fine motor coordination and sensory processing.
GABRA6-specific antibodies are widely used in neuroscience research to investigate receptor localization, expression levels, and functional alterations in diseases such as epilepsy, anxiety disorders, and cerebellar ataxia. They enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize α6-containing receptors in tissues or cultured cells. Dysregulation of GABRA6 has been linked to neurological conditions; for example, mutations or reduced expression may contribute to pathological hyperexcitability or movement disorders. Additionally, GABRA6 antibodies aid in exploring the pharmacological properties of GABAₐ receptors, including responses to benzodiazepines and neurosteroids, which differ across receptor subtypes. This antibody thus serves as a vital resource for understanding GABAergic signaling mechanisms and developing targeted therapies for neurological and psychiatric diseases.
×
