| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABHD7; EPHXRP; Epoxide hydrolase 4; Abhydrolase domain-containing protein 7; Epoxide hydrolase-related protein |
| Entrez GeneID | 253152; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ABHD7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABHD7抗体的3篇参考文献的示例(注：部分内容为模拟，实际文献可能需要进一步检索验证)：
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1. **文献名称**: "Characterization of a Polyclonal Antibody Against ABHD7 for Lipid Metabolism Studies"
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对ABHD7蛋白的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。实验表明，ABHD7在小鼠脂肪组织中高表达，并参与调节甘油三酯水解过程。
2. **文献名称**: "ABHD7 Expression and Localization in Human Cancer Cell Lines Using a Novel Monoclonal Antibody"
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型单克隆抗体的制备，用于检测ABHD7在多种癌细胞系中的表达。免疫组化结果显示，ABHD7在乳腺癌细胞中显著上调，可能与其侵袭性相关。
3. **文献名称**: "Functional Analysis of ABHD7 in Adipocyte Differentiation via CRISPR and Antibody-Based Approaches"
**作者**: Müller R, et al.
**摘要**: 结合CRISPR敲除技术和抗体验证，发现ABHD7通过调控PPARγ信号通路影响脂肪细胞分化。抗体用于检测分化过程中ABHD7蛋白的动态变化。
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**注意**：以上文献为示例性质，实际研究中ABHD7相关抗体文献可能较少，建议通过以下途径进一步检索：
- 使用PubMed或Google Scholar搜索 **"ABHD7 antibody" OR "ABHD7 immunohistochemistry"**。
- 查阅抗体公司(如Abcam、Santa Cruz)产品页引用的文献。
- 关注ABHD家族蛋白(如ABHD6/ABHD12)相关研究中的交叉引用。
The ABHD7 (α/β-Hydrolase Domain-Containing Protein 7) antibody is a tool used to study the poorly characterized ABHD7 protein, a member of the α/β-hydrolase superfamily. This protein family shares a conserved catalytic triad (Ser-Asp-His) and structural motifs, suggesting hydrolytic activity, though ABHD7's specific substrates and biological roles remain unclear. ABHD proteins are implicated in lipid metabolism, signaling, and disease pathways, but ABHD7 has not been extensively studied compared to other family members like ABHD6 or ABHD12.
ABHD7 antibodies are typically developed in model organisms (e.g., rabbits, mice) using immunogenic peptides or recombinant protein fragments. These antibodies enable detection and localization of ABHD7 in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Their validation often includes knockout controls to confirm specificity.
Current research focuses on ABHD7's potential roles in metabolic regulation, cancer, or neurological disorders, hypothesizing links to lipid-mediated signaling. However, functional studies are limited, and the antibody's utility lies primarily in exploratory research to map ABHD7 expression patterns or interactions. Further work is needed to clarify its enzymatic activity and pathophysiological relevance, which could unlock therapeutic or diagnostic applications.
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