| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRP64; 39S ribosomal protein L51, mitochondrial; L51mt; MRP-L51; bMRP-64; bMRP64 |
| Entrez GeneID | 51258; |
| WB Predicted band size | 20kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MRPL51. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPL51抗体的3篇示例参考文献(注：文献为示例性质，具体内容可能需要通过学术数据库核实)：
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1. **文献名称**: *Mitochondrial ribosomal protein L51 regulates apoptosis in human cancer cells*
**作者**: Lee S, et al.
**摘要**: 该研究通过使用MRPL51抗体进行Western blot和免疫荧光实验，发现MRPL51在多种癌细胞系中高表达，并通过调控线粒体膜电位影响细胞凋亡通路。
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2. **文献名称**: *Characterization of mitochondrial ribosome biogenesis using specific antibodies against MRPL51*
**作者**: Zhang Y, et al.
**摘要**: 作者开发了针对MRPL51的多克隆抗体，验证了其在人源细胞线粒体中的特异性定位，并揭示MRPL51在线粒体核糖体组装中的关键作用。
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3. **文献名称**: *MRPL51 mutations impair mitochondrial translation and cause neuromuscular disorders*
**作者**: Smith J, et al.
**摘要**: 利用MRPL51抗体对患者肌肉组织进行免疫组化分析，发现MRPL51功能缺失突变导致线粒体蛋白质合成缺陷，进而引发神经肌肉疾病。
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如需获取真实文献，建议通过PubMed、Google Scholar等平台搜索关键词“MRPL51 antibody”或联系相关抗体供应商获取引用文献。
The MRPL51 antibody is a research tool designed to detect and study the Mitochondrial Ribosomal Protein L51 (MRPL51), a component of the mitochondrial ribosome's large subunit. Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA (mtDNA), which are critical for oxidative phosphorylation (OXPHOS) and cellular energy production. MRPL51. encoded by nuclear DNA, is imported into mitochondria and plays a structural or functional role in assembling or stabilizing the ribosome.
MRPL51 is part of a family of proteins that enable mitochondria to maintain their semi-autonomous protein synthesis machinery. Dysregulation of mitochondrial ribosomal proteins, including MRPL51. has been linked to mitochondrial disorders, metabolic diseases, and cancer, as impaired OXPHOS can drive metabolic reprogramming in tumors. Studies using MRPL51 antibodies often focus on its expression patterns, subcellular localization, or interactions within mitochondrial complexes.
Commercially available MRPL51 antibodies are typically developed in rabbits or mice using immunogenic peptide sequences. They are validated for applications like Western blotting, immunohistochemistry, or immunofluorescence to investigate mitochondrial function, disease mechanisms, or gene expression profiles. Researchers also utilize these antibodies to explore MRPL51's role in cellular stress responses, apoptosis, or mitochondrial biogenesis. Specificity and cross-reactivity remain key validation steps due to homology among ribosomal proteins. Overall, MRPL51 antibodies serve as vital tools for dissecting mitochondrial biology and its implications in health and disease.
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