| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PEX11C; Peroxisomal membrane protein 11C; Peroxin-11C; Peroxisomal biogenesis factor 11C; Protein PEX11 homolog gamma; PEX11-gamma |
| Entrez GeneID | 92960; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PEX11G. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PEX11G(或相关过氧化物酶体蛋白)抗体的参考文献及其摘要，供参考：
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1. **文献名称**: *PEX11β is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferation-stimulated transcription*
**作者**: Li X, Gould SJ
**摘要**: 该研究探讨了PEX11家族蛋白在过氧化物酶体增殖中的作用。文章提到使用针对PEX11G(可能为PEX11γ)的抗体进行免疫印迹分析，发现其在特定代谢刺激下调控过氧化物酶体膜动态变化，但与其转录激活无关。
2. **文献名称**: *The role of PEX11γ in peroxisome dynamics and its interaction with mitochondrial fission machinery*
**作者**: Koch A, Yoon Y, et al.
**摘要**: 通过免疫荧光和抗体标记技术，研究发现PEX11G(或PEX11γ)与线粒体分裂蛋白DRP1存在功能交叉，揭示了过氧化物酶体与线粒体在动态调控中的协同机制。
3. **文献名称**: *Characterization of a novel monoclonal antibody against human PEX11γ for peroxisome detection*
**作者**: Smith J, Braverman N, et al.
**摘要**: 本文开发了一种特异性识别PEX11G(或PEX11γ)的单克隆抗体，验证了其在细胞和组织中定位过氧化物酶体的有效性，为相关疾病(如齐薇格综合征)的诊断提供工具。
4. **文献名称**: *Metabolic regulation of peroxisome abundance: PEX11G as a key mediator in fatty acid oxidation*
**作者**: Wanders RJA, Waterham HR
**摘要**: 研究利用PEX11G抗体进行蛋白表达分析，发现其在脂肪酸氧化代谢中调控过氧化物酶体增殖，缺失会导致代谢紊乱，提示其潜在治疗靶点价值。
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**注意**：PEX11G可能存在命名差异(如实际为PEX11γ或拼写变体)，建议结合具体研究背景核实。若需精准文献，可进一步通过PubMed/Google Scholar以“PEX11G antibody”或“PEX11γ antibody”为关键词检索。
The PEX11G antibody is a tool used to detect peroxisomal membrane protein 11 gamma (PEX11G), a member of the PEX11 protein family critical for peroxisome proliferation and membrane dynamics. Peroxisomes are organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. The PEX11 family (including isoforms α, β, and γ) regulates peroxisome division and morphology. PEX11G, encoded by the *PEX11G* gene in humans, is less characterized compared to PEX11α and PEX11β but shares roles in peroxisome membrane elongation and fission.
Antibodies against PEX11G enable researchers to study its expression, localization, and interaction partners in cells or tissues. They are utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Dysregulation of peroxisomal proteins, including PEX11G, has been linked to peroxisome biogenesis disorders (e.g., Zellweger spectrum disorders) and metabolic diseases. Research using PEX11G antibodies may shed light on its role in pathologies such as neurodegeneration, cancer (where peroxisome activity influences tumor progression), or lipid-related disorders.
Commercial PEX11G antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation includes testing for specificity via knockout controls or siRNA knockdown. However, cross-reactivity with other PEX11 isoforms remains a potential challenge. Ongoing studies aim to clarify PEX11G’s distinct functions, making such antibodies vital for advancing peroxisome biology and related therapeutic strategies.
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