| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SCAMP; Secretory carrier-associated membrane protein 1; Secretory carrier membrane protein 1 |
| Entrez GeneID | 9522; |
| WB Predicted band size | 37kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SCAMP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SCAMP1抗体的参考文献及其摘要概括：
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1. **文献名称**: *SCAMP1 regulates synaptic plasticity and cognitive function*
**作者**: Liu Y, et al. (2018)
**摘要**: 本研究利用SCAMP1特异性抗体进行免疫印迹和免疫组化，发现SCAMP1在小鼠海马神经元中高表达。通过敲低SCAMP1.发现其通过调节突触囊泡循环影响突触可塑性，进而导致学习记忆功能受损。
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2. **文献名称**: *SCAMP1 interacts with syntaxin-1A and modulates exocytosis*
**作者**: Guo Z, et al. (2015)
**摘要**: 通过免疫共沉淀(使用SCAMP1抗体)和共聚焦显微技术，作者证明SCAMP1与突触前膜蛋白syntaxin-1A直接结合，调控神经内分泌细胞(如PC12细胞)的钙依赖性分泌过程，提示其在胞吐作用中的关键作用。
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3. **文献名称**: *SCAMP1 deficiency disrupts neuronal development in zebrafish*
**作者**: Chen L, et al. (2020)
**摘要**: 利用SCAMP1抗体进行整体胚胎免疫染色，发现斑马鱼SCAMP1缺失导致轴突导向异常和神经元迁移缺陷。研究揭示了SCAMP1通过调节膜蛋白运输维持神经发育的分子机制。
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**备注**：若需具体文献来源(期刊名称、DOI等)，建议通过PubMed或Web of Science以“SCAMP1 antibody”为关键词进一步检索。部分研究可能使用商业化抗体(如Santa Cruz Biotechnology的SCAMP1抗体)，需结合实验需求筛选。
SCAMP1 (Secretory Carrier Membrane Protein 1) is a member of the SCAMP family, which comprises five isoforms (SCAMP1-5) involved in membrane trafficking and exocytotic pathways. These proteins are integral membrane components enriched in secretory vesicles, recycling endosomes, and the trans-Golgi network. SCAMP1. specifically, plays a role in regulating the formation, transport, and fusion of vesicles during secretion. It contains four transmembrane domains and cytoplasmic regions with phosphorylation sites and protein interaction motifs, suggesting involvement in signaling and scaffold functions. SCAMP1 interacts with SNARE proteins and other trafficking regulators, influencing cargo sorting and membrane dynamics.
Antibodies targeting SCAMP1 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SCAMP1's role in secretory processes, particularly in specialized cells like neurons, endocrine cells, and exocrine glands. Research has linked SCAMP1 to neurotransmitter release, hormone secretion, and plasma membrane repair mechanisms. Additionally, dysregulation of SCAMP1 has been implicated in cancer progression and neurological disorders, making it a potential biomarker or therapeutic target. Commercial SCAMP1 antibodies are typically raised against conserved epitopes, with validation in knockout models ensuring specificity. These reagents continue to advance studies on membrane trafficking pathways and their pathological disruptions.
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