Rabbit Polyclonal SCN4B Antibody

The SCN4B antibody targets the β4 subunit of voltage-gated sodium channels (Naₓ), which are critical for regulating electrical signaling in excitable cells. The SCN4B gene encodes a protein that modulates the gating kinetics, trafficking, and membrane localization of pore-forming α-subunits (e.g., Naᵥ1.5 in the heart). In the nervous system, β4 subunits influence neuronal excitability and synaptic plasticity, while in cardiac tissue, they stabilize channel inactivation and prevent arrhythmias. SCN4B dysfunction has been linked to cardiac disorders like Brugada syndrome and long QT syndrome, as well as neurological conditions including epilepsy and neuropathic pain. Antibodies against SCN4B are primarily used in research to study its expression, localization, and interaction partners in tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into sodium channel biology and disease mechanisms. Recent studies also explore SCN4B's role in cancer, where altered sodium channel activity may affect cell proliferation and metastasis. The development of specific SCN4B antibodies has been pivotal in dissecting its physiological and pathological roles, offering potential insights for therapeutic targeting in channelopathies.