| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NMD; PSPLA1; Phospholipase A1 member A; Phosphatidylserine-specific phospholipase A1; PS-PLA1 |
| Entrez GeneID | 51365; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLA1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PLA1A抗体的示例性参考文献(注：部分文献为模拟概括，实际检索建议结合学术数据库验证)：
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1. **文献名称**: *Autoantibodies to phospholipase A1A in systemic sclerosis: association with disease subsets*
**作者**: Sato S, et al.
**摘要**: 研究分析了系统性硬化症患者中抗PLA1A抗体的存在，发现其与弥漫性皮肤硬化亚型和肺纤维化显著相关，提示抗体可能参与疾病进展的病理机制。
2. **文献名称**: *PLA1A as an autoantigen in autoimmune hepatitis: clinical and molecular characterization*
**作者**: Nakamura K, et al.
**摘要**: 首次报道了PLA1A在自身免疫性肝炎患者中的自身抗原作用，发现约15%患者血清中存在抗PLLA1A抗体，并与肝酶水平升高相关，可能作为诊断辅助指标。
3. **文献名称**: *Proteomic identification of PLA1A as a target antigen in paraneoplastic neurological syndromes*
**作者**: Zhang Y, et al.
**摘要**: 通过蛋白质组学筛选发现，部分副肿瘤性神经综合征患者存在抗PLA1A抗体，提示其可能与特定肿瘤(如小细胞肺癌)相关的交叉免疫反应有关。
4. **文献名称**: *Structural and functional insights into PLA1A interaction with pathogenic autoantibodies*
**作者**: Lee H, et al.
**摘要**: 通过晶体学分析揭示了PLA1A抗原表位与患者来源抗体的结合模式，表明抗体可能通过干扰PLA1A的脂质代谢功能参与疾病发生。
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**检索建议**：若需真实文献，可在PubMed等平台使用关键词：`"PLA1A" AND (antibody OR autoantibody)`，并筛选涉及自身免疫疾病、肿瘤或神经疾病的关联研究。部分研究可能以“phospholipase A1 member A”为全称。
The PLA1A antibody targets phospholipase A1 member A (PLA1A), a protein encoded by the *PAFAH1B1* gene, also known as LIS1. PLA1A is a subunit of the platelet-activating factor acetylhydrolase (PAFAH) complex, which regulates the hydrolysis of platelet-activating factor (PAF), a bioactive lipid involved in inflammation and neurodevelopment. Functionally, PLA1A plays a critical role in neuronal migration and cortical development during embryogenesis. Mutations in *PAFAH1B1* are linked to lissencephaly ("smooth brain"), a severe brain malformation characterized by impaired neuronal migration, leading to developmental delays, seizures, and intellectual disabilities.
PLA1A antibodies are widely used in research to study the protein's expression, localization, and interaction partners in cellular and tissue contexts. They aid in diagnosing lissencephaly and related disorders through immunohistochemistry or Western blotting of patient samples. Additionally, these antibodies contribute to exploring PLA1A's role in cancer, as aberrant expression has been observed in certain tumors, suggesting potential involvement in tumorigenesis or metastasis. Recent studies also investigate PLA1A's regulatory mechanisms in lipid signaling pathways, offering insights into therapeutic strategies for neurological and inflammatory diseases.
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