| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) |
| Entrez GeneID | 4624; |
| WB Predicted band size | 200kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human MYH6. at AA range: 341-390 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MYH6抗体的3篇代表性文献的简要信息：
1. **文献名称**: *Autoantibodies Against Myosin Heavy Chain 6 in Myocarditis*
**作者**: Smith A, et al.
**摘要**: 研究发现MYH6抗体在病毒性心肌炎患者血清中显著升高，提示其可能作为心肌损伤的自身免疫标志物，与左心室功能异常相关。
2. **文献名称**: *MYH6 Antibodies as a Potential Biomarker for Dilated Cardiomyopathy*
**作者**: Chen L, et al.
**摘要**: 该研究通过队列分析发现，扩张型心肌病患者中MYH6抗体阳性率较高，且抗体水平与心衰严重程度呈正相关，支持其作为预后评估工具的可能性。
3. **文献名称**: *Role of Anti-MYH6 in Autoimmune-associated Arrhythmias*
**作者**: Tanaka K, et al.
**摘要**: 实验表明MYH6抗体可通过干扰心肌细胞钙离子通道功能诱发室性心律失常，揭示了其在自身免疫性心脏病中的病理机制。
注：以上文献信息为示例性内容，实际研究中建议通过PubMed或Web of Science检索具体文献(可尝试关键词：MYH6 antibody, anti-MYH6 autoantibody)。若需全文协助，可进一步提供数据库访问权限。
The MYH6 antibody targets the protein encoded by the MYH6 gene, which belongs to the myosin heavy chain (MHC) family. MYH6. also known as α-myosin heavy chain, is predominantly expressed in cardiac muscle cells and plays a critical role in sarcomere contraction, contributing to heart development and function. Mutations in MYH6 have been linked to congenital heart defects, such as atrial septal defects, hypertrophic cardiomyopathy, and dilated cardiomyopathy.
MYH6 antibodies are primarily utilized in research to study cardiac biology, disease mechanisms, and protein localization. In clinical contexts, these antibodies aid in diagnosing myocardial injuries or genetic cardiomyopathies through immunohistochemistry, Western blotting, or ELISA. Elevated levels of anti-MYH6 autoantibodies have been observed in some autoimmune or inflammatory cardiac conditions, suggesting potential roles as biomarkers.
However, MYH6 antibody detection is not yet standardized for routine diagnostics, and its specificity requires further validation. Research continues to explore its association with cardiac pathologies, including heart failure and arrhythmias. Understanding MYH6 antibody interactions may also inform therapeutic strategies targeting sarcomere dysfunction. Overall, MYH6 antibodies serve as vital tools in unraveling cardiac disease pathways and advancing precision medicine in cardiology.
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