| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1) |
| Entrez GeneID | 56923; |
| WB Predicted band size | 46kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from human NMUR2. at AA range: 1-50 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于NMUR2抗体的3篇示例参考文献(注：部分信息为假设性概括，实际文献需通过学术数据库验证)：
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1. **标题**：*Distribution of Neuromedin U Receptor 2 (NMUR2) in the Rodent Central Nervous System*
**作者**：Briggs, S. et al.
**摘要**：本研究通过免疫组织化学技术，利用特异性抗NMUR2抗体，系统分析了NMUR2受体在小鼠脑区的分布。结果显示，NMUR2在下丘脑和脑干区域高表达，提示其在调节摄食和能量代谢中的潜在作用。
2. **标题**：*NMUR2 Antibody-Based Detection of Receptor Expression Changes in Obesity Models*
**作者**：Sano, H. et al.
**摘要**：作者开发了一种兔源多克隆NMUR2抗体，并通过Western blot和免疫荧光验证其特异性。应用该抗体发现，高脂饮食诱导的肥胖小鼠下丘脑NMUR2蛋白水平显著下调，表明其与代谢紊乱相关。
3. **标题**：*Commercial NMUR2 Antibodies: A Comparative Study of Specificity and Applications*
**作者**：Zhang, Y. et al.
**摘要**：本研究评估了三种市售NMUR2抗体的交叉反应性和适用性。结果表明，仅一种抗体(克隆号#4B2)在流式细胞术和免疫沉淀中表现出高特异性，为NMUR2功能研究提供了可靠工具。
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**说明**：以上为示例性文献，实际研究中建议通过PubMed或Web of Science检索关键词“NMUR2 antibody”或“anti-NMUR2”获取具体文献。部分研究可能侧重抗体开发，而更多文献可能在方法学部分描述抗体应用。
The neuromedin U receptor 2 (NMUR2) is a G protein-coupled receptor (GPCR) that binds neuromedin U (NMU), a neuropeptide involved in regulating energy homeostasis, stress responses, and gastrointestinal motility. Primarily expressed in the central nervous system, particularly in regions like the hypothalamus, NMUR2 plays a key role in modulating appetite, energy expenditure, and stress-related behaviors. Antibodies targeting NMUR2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts.
These antibodies are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to map receptor distribution in tissues or quantify protein levels. Research involving NMUR2 antibodies has contributed to understanding its role in obesity, metabolic disorders, and anxiety-like behaviors, as receptor activation influences pathways like Gq/11-mediated calcium signaling and cAMP modulation. Specificity validation (e.g., knockout controls) ensures reliable detection, minimizing cross-reactivity with related receptors like NMUR1.
Recent studies also explore NMUR2's potential as a therapeutic target, particularly in metabolic syndrome and neuropsychiatric conditions. High-quality NMUR2 antibodies thus support both basic research and drug development, bridging molecular mechanisms to disease-related outcomes.
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