| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) |
| Entrez GeneID | 1310; |
| WB Predicted band size | 130kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from human COL19A1. at AA range: 161-210 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于COL19A1抗体的3篇参考文献示例(内容为模拟概括，建议通过学术数据库核实最新文献)：
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1. **文献名称**：*Collagen XIX is expressed in neuromuscular junctions and regulates synaptic structure*
**作者**：Okada et al.
**摘要**：研究通过COL19A1抗体在小鼠模型中检测到XIX型胶原蛋白在神经肌肉接头处的特异性表达，发现其缺失会导致突触结构异常，提示COL19A1在突触形成中的潜在作用。
2. **文献名称**：*Aberrant expression of collagen XIX in glioblastoma and its association with tumor invasion*
**作者**：Chen et al.
**摘要**：利用COL19A1抗体进行免疫组织化学分析，发现胶质母细胞瘤中COL19A1蛋白表达显著上调，且与肿瘤侵袭性相关，可能成为癌症治疗的潜在靶点。
3. **文献名称**：*Collagen XIX as a novel marker for vascular basement membrane remodeling in diabetic retinopathy*
**作者**：Smith & Patel
**摘要**：通过COL19A1抗体染色，发现糖尿病视网膜病变患者的血管基底膜中胶原XIX异常沉积，提示其在微血管病变中的病理机制。
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注：以上为模拟示例，实际文献请通过PubMed、Google Scholar等平台以“COL19A1 antibody”或“collagen XIX”为关键词检索。
The COL19A1 antibody targets collagen type XIX alpha 1 chain, a non-fibrillar collagen encoded by the COL19A1 gene. This collagen is a minor component of the extracellular matrix (ECM) and is characterized by multiple collagenous domains interrupted by non-collagenous regions. It plays a role in cell adhesion, migration, and tissue organization, particularly during development and tissue repair. COL19A1 is expressed in neural, muscle, and epithelial tissues, with elevated levels observed in specific contexts such as cancer progression, where it may influence tumor microenvironment interactions.
Antibodies against COL19A1 are primarily used in research to study its spatial and temporal expression patterns, ECM remodeling processes, and involvement in diseases. For example, studies link COL19A1 dysregulation to cancers (e.g., breast cancer, glioblastoma), where its overexpression correlates with metastasis and poor prognosis. In neuroscience, it is implicated in synaptic plasticity and neurodegenerative conditions like Alzheimer’s disease. COL19A1 antibodies are employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize protein distribution and quantify expression levels.
Recent interest in COL19A1 stems from its potential as a biomarker or therapeutic target, though its precise mechanisms remain under investigation. Commercial antibodies are typically raised against specific epitopes, such as the N-terminal non-collagenous domain or cysteine-rich regions, and require validation for cross-reactivity given structural similarities among collagen family members. Research continues to explore its dual roles in tissue homeostasis and pathology, emphasizing its context-dependent functions in health and disease.
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