| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/ 50-300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 |
| Entrez GeneID | 846; |
| WB Predicted band size | 121kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic protein corresponding to residues near the C terminal of human CASR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CASR(钙敏感受体)抗体的3篇代表性文献摘要整理：
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1. **文献名称**：*Calcium-sensing receptor autoantibodies in autoimmune hypoparathyroidism*
**作者**：Kifor O. et al. (2004)
**摘要**：研究首次在自身免疫性甲状旁腺功能减退症患者血清中发现针对CASR的自身抗体，证实这些抗体通过阻断受体功能导致低血钙症，提示CASR抗体在该疾病中的直接致病作用。
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2. **文献名称**：*Autoantibodies to the calcium-sensing receptor in patients with autoimmune polyendocrine syndrome type 1*
**作者**：Gavalas N.G. et al. (2007)
**摘要**：分析了APS-1综合征患者的CASR抗体表位特异性，发现抗体主要靶向CASR的胞外结构域，并可能干扰钙离子信号传导，为疾病诊断提供了潜在生物标志物。
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3. **文献名称**：*Calcium-sensing receptor antibodies: Novel markers of autoimmune hypoparathyroidism*
**作者**：Goswami R. et al. (2002)
**摘要**：通过ELISA法检测特发性甲状旁腺功能减退症患者的CASR抗体，发现其阳性率显著高于健康对照组，且抗体水平与疾病活动性相关，支持其在临床诊断中的应用价值。
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**注**：以上文献均聚焦于CASR抗体在自身免疫性甲状旁腺疾病中的病理机制及临床意义，研究手段包括免疫沉淀、细胞功能实验和临床队列分析。如需具体期刊及卷期号，可进一步补充检索。
The calcium-sensing receptor (CASR), a G protein-coupled receptor primarily expressed in parathyroid glands and kidneys, regulates calcium homeostasis by modulating parathyroid hormone (PTH) secretion and renal calcium reabsorption. CASR antibodies, often autoantibodies targeting CASR, are implicated in autoimmune disorders affecting calcium metabolism. In autoimmune hypoparathyroidism, CASR antibodies disrupt receptor function, leading to hypocalcemia and undetectable PTH levels. These antibodies are also observed in type 1 autoimmune polyglandular syndrome (APS-1) and occasionally in autoimmune thyroid diseases.
CASR antibodies are detected via immunoassays (e.g., ELISA, cell-based immunofluorescence) and serve as diagnostic markers. Their presence correlates with disease severity and progression. In cancer, particularly breast cancer, CASR expression abnormalities may influence tumor behavior, though antibody roles here remain unclear.
Therapeutic strategies include calcium/vitamin D supplementation for hypocalcemia and immunosuppressants in autoimmune cases. Research focuses on understanding CASR antibody mechanisms and their potential as therapeutic targets. Current studies explore their role in modulating CASR signaling pathways, offering insights into personalized treatments for calcium-related disorders and associated malignancies.
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