| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/ 20-100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EVI16 |
| Entrez GeneID | 6659; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SOX4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于SOX4抗体的文献概览(基于近年研究，内容为模拟示例)：
1. **文献名称**：*SOX4 mediates EMT in colorectal cancer via Wnt/β-catenin pathway activation*
**作者**：Li X, Zhang Y, et al.
**摘要**：该研究利用SOX4抗体(WB/IHC)验证其在结直肠癌中的高表达，发现SOX4通过激活Wnt通路促进上皮-间质转化(EMT)，推动肿瘤转移。
2. **文献名称**：*A SOX4 antibody-based assay for detecting circulating tumor cells in breast cancer*
**作者**：Wang H, Chen J, et al.
**摘要**：开发了一种基于SOX4抗体的CTC检测方法，证实SOX4阳性CTC与乳腺癌患者预后不良相关，为液体活检提供新靶点。
3. **文献名称**：*SOX4 regulates neuronal differentiation via histone modification*
**作者**：Kim S, Lee D, et al.
**摘要**：通过ChIP-seq结合SOX4抗体，揭示SOX4通过调控组蛋白修饰(如H3K4me3)影响神经干细胞分化为成熟神经元的分子机制。
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*注：以上为示例性内容，实际文献需通过PubMed/Google Scholar检索关键词(如"SOX4 antibody" + "cancer"或具体应用场景)获取。建议优先选择近5年、高影响因子期刊的研究。*
**Background of SOX4 Antibody**
The SOX4 antibody is a crucial tool for studying the SOX4 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX4 belongs to the SOXC subgroup (SOX4. SOX11. SOX12) and plays pivotal roles in embryonic development, cell differentiation, and tissue homeostasis. It is involved in regulating key processes such as neurogenesis, immune system development, and cardiac formation. Structurally, SOX4 contains a conserved HMG domain for DNA binding and a transactivation domain for modulating gene expression.
In cancer research, SOX4 has gained attention as an oncogene implicated in tumor progression, metastasis, and therapy resistance. Overexpression of SOX4 is observed in various cancers, including breast, lung, prostate, and hepatocellular carcinomas, where it promotes epithelial-mesenchymal transition (EMT), stemness, and cell survival. Its role in Wnt/β-catenin, TGF-β, and PI3K/AKT signaling pathways further underscores its oncogenic potential.
The SOX4 antibody enables the detection and quantification of SOX4 protein levels in cells and tissues via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use it to explore SOX4’s spatial expression, interaction partners, and functional mechanisms in both developmental and pathological contexts. Validated antibodies are essential to ensure specificity, particularly given the high homology among SOXC proteins. Commercial SOX4 antibodies are typically raised against epitopes within the unique N- or C-terminal regions, and their utility is confirmed through knockout controls or siRNA-based validation.
Overall, the SOX4 antibody is indispensable for unraveling SOX4’s dual roles in development and disease, offering insights for potential therapeutic targeting.
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