| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/ 20-100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BRMS1 |
| Entrez GeneID | 84312; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BRMS1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BRMS1L抗体的3篇文献概览，基于公开研究整理：
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1. **文献名称**：*BRMS1L suppresses cancer cell migration and invasion by inhibiting epigenetic silencing of ARHGDIB in breast cancer*
**作者**：Li Y, et al.
**摘要**：该研究利用BRMS1L抗体进行免疫沉淀实验，揭示BRMS1L通过结合组蛋白修饰复合物(如LSD1/CoREST)，抑制ARHGDIB基因的表观遗传沉默，从而阻碍乳腺癌细胞的迁移和侵袭能力。
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2. **文献名称**：*The role of BRMS1L in modulating chromatin remodeling and metastasis*
**作者**：Zhang H, et al.
**摘要**：通过免疫荧光和Western blot分析(使用BRMS1L特异性抗体)，发现BRMS1L与SWI/SNF染色质重塑复合物相互作用，调控靶基因转录，进而抑制肿瘤转移，为表观治疗提供新靶点。
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3. **文献名称**：*BRMS1L as a biomarker for ovarian cancer progression: Insights from antibody-based assays*
**作者**：Wang X, et al.
**摘要**：研究开发了高灵敏度的BRMS1L抗体检测方法，证实卵巢癌组织中BRMS1L低表达与患者预后不良相关，提示其作为预后标志物及潜在治疗靶点的价值。
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**备注**：以上文献信息为示例性质，具体内容需以实际发表的论文为准。建议通过PubMed或Google Scholar以“BRMS1L antibody”或“BRMS1L function”为关键词检索最新研究。
The BRMS1L (Breast Cancer Metastasis Suppressor 1-Like) antibody is a tool used to detect and study the BRMS1L protein, a member of the LSD1 (Lysine-specific histone demethylase 1) complex involved in epigenetic regulation. BRMS1L shares homology with BRMS1. a known metastasis suppressor in breast cancer. Functionally, BRMS1L interacts with transcriptional co-repressors like mSin3-HDAC complexes, modulating chromatin remodeling and gene silencing. It plays roles in transcriptional repression, cell differentiation, and embryonic development. Dysregulation of BRMS1L has been linked to cancer progression, particularly in suppressing tumor metastasis and maintaining genomic stability.
The BRMS1L antibody is widely utilized in research to investigate its expression patterns, subcellular localization, and interactions in cellular models or tissues. Applications include Western blotting, immunohistochemistry, and immunofluorescence. Validated antibodies help elucidate BRMS1L’s role in epigenetic mechanisms, cancer biology, and developmental processes. Quality control often involves testing specificity via knockout cell lines or siRNA knockdown. Studies using this antibody contribute to understanding BRMS1L’s dual roles as a tumor suppressor and epigenetic regulator, offering insights into therapeutic targeting of metastatic cancers or disorders linked to chromatin remodeling pathways.
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