| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UAN; Su48; ZNF365D |
| Entrez GeneID | 22891; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNF365 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF365抗体的3篇参考文献示例(内容基于假设性研究，实际文献需通过学术数据库核实)：
1. **文献名称**：*ZNF365 regulates DNA repair and genomic stability in breast cancer*
**作者**：Smith A, et al.
**摘要**：本研究通过ZNF365抗体进行免疫沉淀和Western blot分析，发现ZNF365蛋白通过与BRCA1相互作用参与DNA双链断裂修复，其表达缺失会增加乳腺癌细胞对放疗的敏感性。
2. **文献名称**：*ZNF365 variants influence inflammatory bowel disease via NF-κB signaling*
**作者**：Zhang L, et al.
**摘要**：利用ZNF365抗体进行免疫组化实验，发现ZNF365在肠道上皮细胞中高表达，并通过抑制NF-κB通路减轻炎症反应。研究提示ZNF365可能是IBD治疗的潜在靶点。
3. **文献名称**：*ZNF365 interacts with telomeric proteins and maintains chromosomal integrity*
**作者**：Wang Y, et al.
**摘要**：通过ChIP-seq结合ZNF365抗体，揭示了ZNF365在端粒区域的富集，并证明其通过与Shelterin复合物协同维持端粒稳定性，缺失会导致染色体异常和细胞衰老。
(注：以上为模拟内容，实际文献请通过PubMed、Google Scholar等平台以“ZNF365 antibody”或“ZNF365 function”为关键词检索。)
The ZNF365 antibody targets the zinc finger protein 365 (ZNF365), a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger domains involved in DNA binding and transcriptional regulation. ZNF365 has garnered attention due to its role in cellular processes such as DNA repair, cell cycle regulation, and apoptosis. Genetic studies have linked ZNF365 variants to human diseases, including atopic dermatitis, breast cancer, and age-related macular degeneration, highlighting its potential role in maintaining genomic stability and tissue homeostasis.
Two major isoforms, ZNF365A and ZNF365B, derived from alternative splicing, exhibit distinct functions. ZNF365A interacts with proteins like RAD50 to facilitate DNA double-strand break repair, while ZNF365B regulates mRNA stability and translation. Antibodies specific to ZNF365 are critical tools for detecting these isoforms in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They enable researchers to study ZNF365's expression patterns, subcellular localization, and interactions in disease models. Commercially available antibodies are often validated for specificity, given the protein’s homology with other zinc finger family members. Recent studies using ZNF365 antibodies have revealed its downregulation in certain cancers, suggesting tumor-suppressive roles. These findings underscore its relevance in biomedical research, particularly in understanding mechanisms of carcinogenesis and developing therapeutic strategies targeting DNA repair pathways.
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