Rabbit Polyclonal ALS2CL Antibody

ALS2CL antibody is designed to detect the C-terminal truncated isoform of alsin, a protein encoded by the ALS2 gene. Alsin, predominantly expressed in the central nervous system, plays critical roles in neuronal maintenance, including endosomal trafficking, GTPase regulation, and cytoskeletal dynamics. Mutations in ALS2 are linked to rare juvenile-onset neurodegenerative disorders, such as autosomal recessive amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and infantile-onset ascending hereditary spastic paralysis. The ALS2CL isoform arises from alternative splicing, producing a truncated protein lacking part of the C-terminal region. This truncation may alter its cellular localization or functional interactions, potentially contributing to disease mechanisms. The ALS2CL antibody is commonly used in research to distinguish the truncated isoform from full-length alsin, aiding studies on ALS2-related pathology, protein expression patterns in disease models, and isoform-specific functional analyses. Its applications include immunohistochemistry, Western blotting, and immunofluorescence, helping to elucidate the molecular basis of ALS2-associated neurodegeneration and validate experimental models. This tool is essential for exploring alsin's dual roles in health and disease, particularly in understanding how isoform diversity impacts neuronal survival pathways.