Rabbit Polyclonal PRTFDC1 Antibody

The PRTFDC1 (Phosphoribosyl Transferase Domain Containing 1) gene, also known as HPRT or HPRT1L, encodes a protein initially hypothesized to function as a purine metabolic enzyme due to its homology with hypoxanthine-guanine phosphoribosyltransferase (HPRT). However, subsequent studies revealed it lacks enzymatic activity, suggesting a distinct biological role. PRTFDC1 has garnered attention in cancer research, particularly in head and neck squamous cell carcinoma (HNSCC), where its frequent deletion or epigenetic silencing at chromosome 10q23.3 correlates with tumor progression. Antibodies targeting PRTFDC1 are primarily used to investigate its expression patterns, subcellular localization, and potential tumor-suppressive functions. Immunohistochemical analyses using PRTFDC1 antibodies have demonstrated reduced protein levels in oral squamous cell carcinomas compared to normal tissues, supporting its proposed role in tumorigenesis suppression. These antibodies also facilitate studies exploring PRTFDC1's interaction partners and signaling pathways, particularly those involving purine metabolism and cellular proliferation. Recent research indicates PRTFDC1 may participate in nucleotide salvage pathways or act as a regulatory protein, though its precise mechanism remains under investigation. Commercial PRTFDC1 antibodies are typically validated for applications including Western blotting, immunofluorescence, and formalin-fixed paraffin-embedded tissue staining, enabling both basic research and clinical biomarker studies.