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Rabbit Polyclonal GALE Antibody

  • 中文名： GALE抗体
  • 别    名： SDR1E1
货号: IPDX43437
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSDR1E1
Entrez GeneID2582;
WB Predicted band size38kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GALE
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GALE(UDP-galactose-4-epimerase)抗体的3篇代表性文献摘要示例(注：文献为虚构示例，实际引用需查询数据库)：

1. **文献名称**：*"Development of a High-Specificity Monoclonal Antibody for Human GALE Protein Detection"*

**作者**：Smith A, et al.

**摘要**：本研究开发了一种针对人源GALE蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性，为半乳糖代谢异常的诊断提供了工具。

2. **文献名称**：*"GALE Deficiency Screening Using Antibody-Based Assays in Clinical Samples"*

**作者**：Chen L, et al.

**摘要**：通过抗GALE抗体建立ELISA检测方法，分析了疑似半乳糖血症患者的GALE蛋白表达水平，发现与基因突变相关的酶活性降低。

3. **文献名称**：*"Subcellular Localization of GALE in Mammalian Cells Revealed by Immunofluorescence"*

**作者**：Wang Y, et al.

**摘要**：利用特异性多克隆抗体结合荧光标记技术，揭示了GALE蛋白在细胞质中的分布模式，并探讨其与代谢调控网络的关联。

(提示：实际文献需通过PubMed或Google Scholar以关键词“GALE antibody”或“UDP-galactose-4-epimerase antibody”检索。)

背景信息

The GALE antibody targets UDP-galactose-4-epimerase (GALE), a critical enzyme in the Leloir pathway responsible for galactose metabolism. GALE catalyzes the interconversion of UDP-galactose and UDP-glucose, essential for maintaining cellular glycosylation and energy homeostasis. Mutations in the GALE gene are linked to galactosemia type III, a rare metabolic disorder characterized by impaired galactose processing, leading to complications like liver dysfunction, developmental delays, and cataracts. Research on GALE antibodies has been pivotal in studying enzyme expression, localization, and dysfunction in disease models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess GALE protein levels in tissues or cell lines, aiding in diagnosing genetic variants and understanding molecular mechanisms underlying galactosemia. Recent studies also explore GALE's role beyond galactosemia, including its potential involvement in cancer progression and glycobiology. Monoclonal and polyclonal GALE antibodies are commercially available, with validation for specificity and sensitivity across species. Ongoing work focuses on refining antibody-based assays to support therapeutic development, such as enzyme replacement therapies or small-molecule correctors for GALE-deficient conditions.

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