Rabbit Polyclonal HPD Antibody

The 4-hydroxyphenylpyruvate dioxygenase (HPD) antibody is a tool used to study HPD, a key enzyme in tyrosine metabolism. HPD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate, a critical step in the degradation of tyrosine. Dysregulation of HPD activity is linked to hereditary tyrosinemia type III and has implications in liver diseases, metabolic disorders, and neurodegenerative conditions. HPD antibodies are primarily employed in biomedical research to detect and quantify HPD expression in tissues or cell lines, aiding in the investigation of its physiological roles and disease associations. They are utilized in techniques like Western blotting, immunohistochemistry, and ELISA. Additionally, HPD has gained attention as a therapeutic target; its inhibition by drugs like nitisinone reduces toxic tyrosine metabolites in tyrosinemia type I. Research using HPD antibodies also explores its potential involvement in oxidative stress pathways and metabolic syndrome. Commercial HPD antibodies are typically developed in animal hosts (e.g., rabbit, mouse) and validated for species reactivity (human, rat, mouse). Recent studies focus on HPD's interaction with other metabolic enzymes and its tissue-specific expression patterns. Proper validation of antibody specificity remains crucial, as cross-reactivity with structurally similar dioxygenases may occur.