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Rabbit Polyclonal TXNDC11 Antibody

  • 中文名: TXNDC11抗体
  • 别    名: EFP1
货号: IPDX43403
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSRK; STD; TZK
Entrez GeneID7535
clone3D2A4
WB Predicted band size70kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ZAP70 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TXNDC11抗体的3篇示例参考文献(注:部分内容为模拟示例,实际文献需通过学术数据库验证):

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1. **文献名称**: "TXNDC11 modulates endoplasmic reticulum-mitochondria interactions through redox regulation"

**作者**: Lee, S. et al.

**摘要**: 本研究利用特异性TXNDC11抗体,通过免疫荧光和共聚焦显微镜技术,揭示了TXNDC11通过硫氧还蛋白活性调控内质网与线粒体间钙离子信号传导的机制。结果表明,TXNDC11缺失导致氧化应激下细胞凋亡增强。

2. **文献名称**: "Development of a polyclonal antibody against human TXNDC11 and its application in hepatocellular carcinoma"

**作者**: Zhang, Y. et al.

**摘要**: 研究团队成功制备并验证了一种高特异性TXNDC11多克隆抗体,应用于肝细胞癌组织样本的免疫组化分析。结果显示,TXNDC11在癌旁组织中高表达,且与患者生存率呈负相关。

3. **文献名称**: "Proteomic profiling identifies TXNDC11 as a novel biomarker in Alzheimer’s disease"

**作者**: Johnson, R.B. et al.

**摘要**: 通过Western blot和免疫沉淀技术(使用商业化TXNDC11抗体),研究发现阿尔茨海默病患者脑脊液中TXNDC11蛋白水平显著升高,提示其可能参与tau蛋白异常磷酸化过程。

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**备注**:以上文献为示例性质,实际研究中建议通过PubMed、Google Scholar等平台以关键词“TXNDC11 antibody”或“TXNDC11 function”检索最新结果。若研究较少,可扩展检索硫氧还蛋白家族(thioredoxin family)或相关通路文献。

背景信息

The TXNDC11 antibody is a crucial tool for studying the thioredoxin domain-containing 11 (TXNDC11) protein, a member of the thioredoxin superfamily involved in redox regulation and protein folding. TXNDC11. also known as endoplasmic reticulum protein 44 (ERp44), localizes primarily to the endoplasmic reticulum (ER) and plays a role in oxidative protein folding, calcium homeostasis, and quality control of secretory proteins. It interacts with other ER-resident chaperones, such as BiP and protein disulfide isomerase (PDI), to assist in the formation of disulfide bonds and prevent protein misfolding. TXNDC11 antibodies are typically produced in rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable the detection and analysis of TXNDC11 expression levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research applications span cancer biology, neurodegenerative diseases, and metabolic disorders, where TXNDC11 dysregulation is linked to ER stress, apoptosis, and pathological protein aggregation. Validated antibodies are essential for investigating TXNDC11's role in cellular stress responses and its potential as a therapeutic target. Specificity is confirmed using knockout controls or siRNA-mediated silencing to ensure accurate experimental outcomes.

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