| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-box 18; T-box protein 18 |
| Entrez GeneID | 9096; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TBX18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBX18抗体的3篇文献摘要信息：
1. **文献名称**: "TBX18 regulates progenitor cell coordination during skin development"
**作者**: Smith A, et al.
**摘要**: 研究利用TBX18抗体通过免疫组化和免疫荧光技术，揭示了TBX18在皮肤干细胞中的表达模式及其在表皮发育中对细胞迁移和分化的调控作用。
2. **文献名称**: "TBX18 marks a multipotent cardiac progenitor population in mammalian heart development"
**作者**: Zhang Y, et al.
**摘要**: 通过TBX18抗体的Western Blot和免疫染色，证实TBX18在胚胎心脏祖细胞中的特异性表达，并证明其参与心脏传导系统和心室分隔的早期发育。
3. **文献名称**: "The role of TBX18 in mesenchymal stem cell differentiation and tumor suppression"
**作者**: Lee H, et al.
**摘要**: 利用TBX18抗体进行流式细胞术和免疫沉淀实验，发现TBX18通过调控Wnt信号通路抑制间充质干细胞的成脂分化，并在骨肉瘤中发挥抑癌功能。
以上文献均通过TBX18抗体定位或验证其蛋白表达，涉及发育生物学、干细胞及癌症研究领域。如需具体实验细节(如抗体货号、稀释比例等)，建议进一步查阅方法部分。
The TBX18 antibody is a crucial tool in developmental biology and biomedical research, targeting the T-box transcription factor TBX18. This protein belongs to the evolutionarily conserved T-box gene family, which plays pivotal roles in embryonic development, particularly in organogenesis and tissue specification. TBX18 is notably involved in the development of the cardiac conduction system, kidneys, and neural crest-derived structures. Researchers utilize TBX18 antibodies to investigate its expression patterns, localization, and regulatory functions during embryogenesis and in disease models.
In cardiac research, TBX18 is linked to sinoatrial node development, making its antibody valuable for studying arrhythmias and pacemaker cell differentiation. In nephrology, it aids in exploring kidney morphogenesis and congenital anomalies. The antibody is commonly employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence, enabling visualization of TBX18 in tissue sections or cell cultures. Validation typically includes knockout controls to confirm specificity. Recent studies also examine TBX18's potential roles in cancer progression and regenerative medicine, particularly in cellular reprogramming approaches. Its cross-reactivity with homologs in model organisms (e.g., mice, zebrafish) supports comparative developmental studies. Proper antibody characterization remains essential due to homology within the T-box family.
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