| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RHD; Blood group Rh(D) polypeptide; RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen; CD240D |
| Entrez GeneID | 6007; |
| WB Predicted band size | 45kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human CD240d. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD240D抗体的3篇文献示例(内容基于领域知识模拟，建议通过学术数据库核实具体文献)：
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1. **标题**：*CD240D in the Rh Antigen Complex: Structural and Functional Insights*
**作者**：Daniels, G., Avent, N.D.
**摘要**：研究Rh抗原复合体中CD240D(RhD)的分子结构及其与CD240CE的结合机制，揭示其在红细胞膜稳定性及抗原性中的作用，为溶血性疾病机制提供理论依据。
2. **标题**：*Anti-CD240D Antibodies in Autoimmune Hemolytic Anemia: Clinical Significance*
**作者**：Westhoff, C.M., et al.
**摘要**：分析自身免疫性溶血性贫血(AIHA)患者中抗CD240D抗体的出现频率及其与溶血严重程度的关系，强调抗体检测在输血和临床管理中的关键作用。
3. **标题**：*Genetic Variants of CD240D and Implications for Antibody Reactivity*
**作者**：Hernandez, A., et al.
**摘要**：探讨CD240D基因多态性对Rh抗原表位多样性的影响，揭示特定变异如何导致输血或妊娠中抗体识别差异，为精准血型匹配提供数据支持。
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**提示**：建议通过PubMed或Google Scholar搜索关键词“CD240D antibody”“RhD antigen”或“Rh blood group system”获取真实文献。
CD240d antibody targets the CD240d antigen, a component of the Rh blood group system, specifically associated with the RhD antigen. The Rh system, discovered in the 1940s, is critical in transfusion medicine due to its immunogenicity. CD240d (RhD) is a transmembrane protein expressed on red blood cells (RBCs), encoded by the *RHD* gene. It forms a complex with CD240ce (RhCE) and Rh-associated glycoprotein (RhAG), maintaining RBC membrane integrity and facilitating gas transport.
Anti-CD240d antibodies are typically IgG, developed after exposure to RhD-positive RBCs via transfusion, pregnancy, or transplantation. Incompatibility (RhD-negative individuals exposed to RhD-positive blood) can trigger hemolytic transfusion reactions or hemolytic disease of the fetus/newborn (HDFN). Historically, anti-D prophylaxis (e.g., Rho(D) immune globulin) has drastically reduced HDFN incidence.
CD240d antibodies are detected via agglutination or antiglobulin tests. Clinically, they guide safe blood matching and prenatal care. Research explores their role in autoimmune hemolytic anemia and structural interactions within the Rh complex. Despite advances, mechanisms underlying RhD antigenicity and antibody-mediated hemolysis remain partially understood, driving ongoing studies in immunohematology and RBC biology.
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