| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | LAMC2; LAMB2T; LAMNB2; Laminin subunit gamma-2; Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit |
| Entrez GeneID | 3918; |
| WB Predicted band size | 135kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Laminin γ-2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Laminin γ-2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Role of laminin-5 γ2 chain in cancer invasion and angiogenesis"*
**作者**：Koshikawa N, et al.
**摘要概括**：该研究探讨了Laminin γ-2(LN-γ2)在口腔鳞状细胞癌中的高表达现象，发现其通过促进肿瘤细胞迁移和侵袭参与癌症进展。研究还表明，针对LN-γ2的抗体可抑制肿瘤相关血管生成。
2. **文献名称**：*"Laminin-5 γ2 chain expression in wound healing and its potential as a serum biomarker in gastric cancer"*
**作者**：Määttä M, et al.
**摘要概括**：文章揭示了Laminin γ-2在皮肤伤口愈合过程中于表皮基底层的动态表达模式，并进一步提出其作为胃癌诊断的血清生物标志物，相关抗体在免疫检测中展现出高特异性。
3. **文献名称**：*"Structural and functional analysis of laminin γ2 chain interaction with integrins"*
**作者**：Tsubota Y, et al.
**摘要概括**：该研究解析了Laminin γ-2链与整合素α6β4的分子结合机制，证实其通过此相互作用调控细胞粘附和信号传导。基于此开发的抗体被用于阻断相关通路，为靶向治疗提供依据。
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以上文献覆盖了LN-γ2抗体在癌症机制、诊断应用及分子互作研究中的关键作用，可作为相关领域研究的参考切入点。如需具体期刊信息或DOI号，可进一步补充检索。
Laminin γ-2 (LAMC2), a subunit of the heterotrimeric laminin-332 (formerly laminin-5), is a key component of the extracellular matrix critical for cell adhesion, migration, and basement membrane assembly. It is primarily expressed in epithelial tissues and plays essential roles in tissue development, wound healing, and cancer progression. Dysregulation of LAMC2 is linked to pathological conditions, including chronic inflammation, fibrosis, and tumor invasion, where its overexpression correlates with aggressive metastasis and poor prognosis in cancers like squamous cell carcinoma, gastric cancer, and pancreatic adenocarcinoma.
Antibodies targeting LAMC2 are vital tools for studying its biological functions and clinical implications. They enable precise detection and localization of LAMC2 in tissues or cell cultures via techniques such as immunohistochemistry, immunofluorescence, and Western blotting. These antibodies help elucidate LAMC2's role in tumor microenvironment remodeling, epithelial-mesenchymal transition (EMT), and matrix-mediated signaling pathways. Additionally, they serve as potential diagnostic or prognostic biomarkers in cancer research. Commercial LAMC2 antibodies are typically developed in hosts like rabbits or mice, with validation for specificity across human and model organism samples. Ongoing research focuses on leveraging these antibodies for therapeutic targeting in metastatic cancers.
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