| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | SLK; KIAA0204; STK2; STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2 |
| Entrez GeneID | 9748; |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the C-terminal region of human SLK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于SLK抗体的3篇参考文献的简要概括(注：部分文献为示例性描述，建议通过学术数据库核实具体内容)：
1. **文献名称**：*"SLK-mediated phosphorylation of paxillin is required for fibrotic responses in mesenchymal cells"*
**作者**：Smith A, et al.
**摘要**：该研究利用SLK特异性抗体，通过免疫印迹和免疫荧光技术，揭示了SLK激酶在成纤维细胞纤维化反应中的作用。研究发现SLK通过磷酸化paxillin蛋白调控细胞黏附和迁移，为纤维化疾病提供了潜在治疗靶点。
2. **文献名称**：*"Ste20-like kinase SLK regulates neuronal migration via interaction with focal adhesion proteins"*
**作者**：Chen L, et al.
**摘要**：作者通过SLK抗体进行免疫共沉淀实验，发现SLK与黏着斑蛋白复合物相互作用，调控神经元迁移过程。研究证实SLK抗体在体外和脑组织切片中的特异性，为神经发育障碍机制提供了新见解。
3. **文献名称**：*"Antibody-based profiling of SLK expression in human cancers reveals prognostic significance"*
**作者**：Wang X, et al.
**摘要**：该研究开发了高特异性SLK单克隆抗体，用于分析多种癌症组织中SLK蛋白的表达水平。结果显示，SLK在乳腺癌和结肠癌中高表达，且与患者生存率负相关，提示其作为癌症生物标志物的潜力。
(注：以上文献为示例性内容，实际文献需通过PubMed/Google Scholar检索关键词如“SLK antibody”、“Ste20-like kinase application”等获取。)
**Background of SLK Antibody**
The Ste20-like kinase (SLK), a serine/threonine protein kinase, plays critical roles in regulating cellular processes such as apoptosis, cell migration, cytoskeletal reorganization, and response to stress. It belongs to the germinal center kinase (GCK) subfamily, characterized by its ability to activate MAPK pathways and modulate signaling cascades involved in development, tissue repair, and disease. SLK is unique in its dual capacity to promote both cell survival and apoptosis, depending on cellular context and stimuli.
SLK antibodies are essential tools for studying its expression, localization, and function. They enable detection of SLK in various techniques, including Western blotting, immunohistochemistry, and immunofluorescence. Research has linked SLK dysregulation to pathological conditions such as cancer, fibrosis, and neurodegenerative disorders. For instance, elevated SLK levels are observed in certain cancers, where it may drive metastasis or chemoresistance, while its downregulation is implicated in impaired tissue regeneration.
These antibodies also aid in exploring SLK's interaction with substrates like LATS1/2 in the Hippo pathway and its role in cross-talk with other signaling networks (e.g., TGF-β, Wnt). By facilitating mechanistic studies, SLK antibodies contribute to understanding its therapeutic potential as a target for diseases involving uncontrolled proliferation or apoptosis. Continued development of high-specificity SLK antibodies remains vital for advancing both basic research and clinical applications.
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