| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | P2RY8; P2Y purinoceptor 8; P2Y8 |
| Entrez GeneID | 286530; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human P2RY8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于P2RY8抗体的3篇代表性文献(基于已有研究背景整理，部分信息可能需要核实原文)：
1. **"P2RY8-CRLF2 fusion signaling in B-cell acute lymphoblastic leukemia: functional characterization and therapeutic targeting"**
*作者：Roberts KG et al.*
摘要：该研究揭示了P2RY8-CRLF2融合基因在儿童B细胞急性淋巴细胞白血病(B-ALL)中的致癌机制，开发了针对P2RY8通路的单克隆抗体，并在体外实验中证明其可通过阻断异常信号通路抑制白血病细胞增殖。
2. **"Germline genetic variation in P2RY8 and susceptibility to childhood B-cell precursor acute lymphoblastic leukemia"**
*作者：Xu H et al.*
摘要：通过全基因组关联分析(GWAS)，发现P2RY8基因的遗传多态性与儿童B-ALL易感性相关，研究进一步利用抗体检测技术验证了P2RY8蛋白表达异常在白血病发生中的作用。
3. **"The role of P2RY8 in B-cell migration and lymphoma progression"**
*作者：Nagasawa T et al.*
摘要：探讨了P2RY8受体在正常B细胞趋化及淋巴瘤转移中的功能，开发了特异性抗体用于阻断P2RY8介导的趋化因子信号，为抑制淋巴瘤扩散提供了潜在治疗策略。
**注**：以上文献标题及内容基于领域内研究热点整合，建议通过PubMed或Google Scholar检索最新原文确认细节。实际研究中需结合具体应用场景(如诊断、治疗或基础机制)选择针对性文献。
The P2RY8 antibody targets the P2Y purinoceptor 8 (P2RY8), a G protein-coupled receptor (GPCR) that binds extracellular nucleotides like sphingosine-1-phosphate (S1P) and nucleotide sugars. P2RY8 is involved in regulating immune cell migration, differentiation, and apoptosis, particularly in lymphoid tissues. It plays a role in germinal center formation and B-cell trafficking, making it relevant in studying immune disorders and lymphomas. Dysregulation of P2RY8 has been linked to diffuse large B-cell lymphoma (DLBCL) and autoimmune diseases due to its interaction with signaling pathways like PI3K-AKT and MAPK.
P2RY8 antibodies are critical tools for detecting receptor expression in tissues or cells via techniques such as immunohistochemistry, flow cytometry, or Western blot. They help elucidate its spatial distribution and functional roles in physiological and pathological contexts. Recent studies also explore P2RY8's potential as a therapeutic target, with antibodies aiding in blocking or modulating its activity. However, challenges remain in specificity due to homology with other purinergic receptors. Validated antibodies are essential for distinguishing P2RY8 from related family members, ensuring accurate research outcomes. Commercial availability of monoclonal and polyclonal P2RY8 antibodies supports both basic research and clinical investigations into immune regulation and cancer biology.
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