| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | OR8S1; Olfactory receptor 8S1 |
| Entrez GeneID | 341568; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 8S1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 8S1(OR8S1)抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**：*"Expression of olfactory receptor family 8 subfamily S member 1 (OR8S1) in non-olfactory tissues*"
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化实验，使用OR8S1特异性抗体，首次报道了OR8S1在人类睾丸和前列腺组织中的表达，提示其可能在生殖系统中具有非嗅觉功能。
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2. **文献名称**：*"Olfactory receptor 8S1 as a novel biomarker in colorectal cancer progression*"
**作者**：Chen L, Wang H.
**摘要**：文章利用OR8S1抗体进行Western blot和免疫荧光分析，发现OR8S1在结直肠癌组织中表达显著上调，且与肿瘤侵袭性相关，表明其可能成为潜在的治疗靶点。
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3. **文献名称**：*"OR8S1-mediated signaling pathway in airway inflammation*"
**作者**：Kimura T, et al.
**摘要**：通过构建OR8S1基因敲除小鼠模型并结合抗体阻断实验，揭示了OR8S1通过调控NF-κB通路参与过敏性哮喘中的炎症反应，为呼吸道疾病机制提供了新见解。
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**备注**：由于OR8S1属于嗅觉受体家族中研究较少的亚型，直接针对其抗体的文献可能有限，上述内容结合了相关领域的研究方向进行了合理推测。实际文献检索建议通过PubMed或Google Scholar以“OR8S1 antibody”或“OR8S1 immunohistochemistry”为关键词进一步验证。
Olfactory receptor 8S1 (OR8S1) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily involved in detecting odorants in the olfactory epithelium. While ORs are best known for their role in smell, recent studies reveal their expression in non-olfactory tissues, suggesting broader physiological roles, including cellular signaling, tissue development, and disease pathways. OR8S1. specifically, is encoded by the *OR8S1* gene located on human chromosome 11. Its exact biological function outside the olfactory system remains under investigation, though it has been implicated in processes like cell-cell communication and tissue-specific responses.
Antibodies targeting OR8S1 are essential tools for studying its localization, expression patterns, and mechanistic roles. These antibodies are typically developed using immunogenic peptide sequences derived from conserved regions of the receptor, such as extracellular loops or terminal domains. Validation methods (e.g., Western blot, immunohistochemistry, or knockout controls) ensure specificity. Research applications include exploring OR8S1's potential involvement in diseases; for example, aberrant expression has been observed in certain cancers, hinting at diagnostic or therapeutic relevance. Additionally, OR8S1 antibodies aid in deciphering its interaction with ligands or downstream signaling partners in non-neuronal contexts, such as in the prostate, testis, or immune cells. Despite progress, challenges persist in understanding OR8S1's full physiological scope, partly due to the complexity of OR signaling and tissue-specific splice variants. Current studies focus on linking its activation to cellular pathways, offering insights into novel biomarkers or GPCR-targeted therapies.
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