| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ORAOV1; TAOS1; Oral cancer-overexpressed protein 1; Tumor-amplified and overexpressed sequence 1 |
| Entrez GeneID | 220064; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human ORAOV1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ORAOV1抗体的3篇示例文献(注：文献信息为模拟示例，实际引用需查询数据库)：
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1. **文献名称**: *"ORAOV1 as a novel biomarker in head and neck squamous cell carcinoma: immunohistochemical analysis"*
**作者**: Smith J, et al.
**摘要**: 研究通过免疫组化技术验证了ORAOV1抗体在头颈鳞状细胞癌组织中的特异性表达，发现ORAOV1高表达与肿瘤侵袭性及患者预后不良显著相关，提示其作为潜在诊断标志物的价值。
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2. **文献名称**: *"Overexpression of ORAOV1 correlates with poor prognosis in esophageal squamous cell carcinoma"*
**作者**: Zhang L, et al.
**摘要**: 利用ORAOV1抗体对食管鳞癌组织进行染色分析，发现ORAOV1在癌变区域显著过表达，且与淋巴结转移、临床分期及患者生存率降低相关，支持其作为预后评估指标的应用。
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3. **文献名称**: *"Functional characterization of ORAOV1 in tumor angiogenesis via antibody-mediated knockdown"*
**作者**: Chen H, et al.
**摘要**: 通过特异性ORAOV1抗体阻断实验，揭示了ORAOV1通过调控VEGF信号通路促进肿瘤血管生成的分子机制，为靶向治疗提供了实验依据。
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**建议**：实际文献可通过PubMed、Google Scholar等平台以关键词“ORAOV1 antibody”、“ORAOV1 cancer”检索，重点关注抗体应用在疾病机制、诊断或治疗的研究。
The ORAOV1 (Oral Cancer Overexpressed 1) gene, located on chromosome 11q13. was initially identified due to its frequent amplification and overexpression in oral squamous cell carcinomas. This genomic region (11q13) is a well-known hotspot for oncogenic alterations in multiple cancers, including head and neck, breast, and ovarian cancers. ORAOV1 encodes a conserved transmembrane protein of unknown precise function, though it is hypothesized to play roles in cell proliferation, survival, and tumor progression. Studies suggest its involvement in metabolic pathways, potentially influencing mitochondrial function or redox regulation.
ORAOV1-specific antibodies are essential tools for detecting and quantifying ORAOV1 protein expression in research. These antibodies enable the investigation of ORAOV1's cellular localization (primarily membrane-associated), expression patterns across tissues, and dysregulation in malignancies. Commercially available antibodies, often polyclonal or monoclonal IgG types, are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using ORAOV1 antibodies has linked its overexpression to poor prognosis in cancers, supporting its potential as a diagnostic biomarker or therapeutic target. However, functional studies remain ongoing to fully elucidate its mechanistic contributions to oncogenesis.
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