| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | Cathepsin O, CTSO, CTSO1 |
| Entrez GeneID | 1519 |
| WB Predicted band size | 36.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CTSO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human CTSO. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于p140Cap抗体的3篇参考文献及其摘要内容的简要列举：
1. **文献名称**：*p140Cap inhibits breast cancer progression through metastasis suppression*
**作者**：Manfroi, B. 等
**摘要**：该研究利用p140Cap特异性抗体，通过免疫印迹和免疫组化分析，发现p140Cap通过抑制Src信号通路降低乳腺癌细胞的迁移和转移能力，提示其作为预后生物标志物的潜力。
2. **文献名称**：*p140Cap regulates the neuronal differentiation and synaptic plasticity in cortical neurons*
**作者**：Diaconu, M. 等
**摘要**：通过免疫荧光和共聚焦显微镜技术结合p140Cap抗体，研究发现p140Cap蛋白在大脑皮层神经元突触形成中起关键作用，并参与神经递质受体的动态调控。
3. **文献名称**：*p140Cap expression correlates with better survival in colorectal cancer by blocking oncogenic pathways*
**作者**：Crisà, E. 等
**摘要**：研究采用p140Cap抗体对结肠癌组织进行免疫组化分析，发现高表达p140Cap的患者预后较好，其机制可能与抑制EGFR/ERK信号通路的过度激活有关。
4. **文献名称**：*Tyrosine phosphorylation of p140Cap modulates its adaptor function in cancer cells*
**作者**：Cabodi, S. 等
**摘要**：通过免疫沉淀和磷酸化特异性抗体技术，揭示了p140Cap的酪氨酸磷酸化状态影响其与下游信号分子(如FAK和Cas)的相互作用，从而调控肿瘤细胞的黏附和侵袭行为。
(注：以上文献信息为示例性整理，实际引用需以具体发表的论文内容为准。)
The p140Cap protein, also known as SNIP (Src kinase signaling inhibitor 1-associated phosphoprotein), is a scaffolding protein involved in regulating cellular signaling pathways, particularly those linked to tyrosine kinase receptors. Initially identified in studies of breast cancer, p140Cap is encoded by the *SORBS1* gene and plays a role in modulating cell adhesion, proliferation, and migration. Its expression is often associated with tumor suppression, as it inhibits cancer progression and metastasis by interfering with oncogenic signaling cascades, such as those mediated by ERBB2/HER2 and Src kinase.
Antibodies targeting p140Cap are essential tools in biomedical research for detecting its expression and localization in tissues or cell lines. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study p140Cap's role in cancer biology and other diseases. Research has shown that p140Cap expression is frequently downregulated in aggressive cancers, including breast, colon, and neuroblastoma, correlating with poor clinical outcomes. Conversely, its presence is linked to enhanced therapeutic responses, making it a potential biomarker for prognosis or treatment stratification.
Structurally, p140Cap contains multiple protein-binding domains, enabling interactions with signaling molecules like SNAP-25 and FAK. Phosphorylation at specific tyrosine residues regulates its activity, emphasizing its dynamic role in cellular signaling. Continued research using p140Cap antibodies aims to unravel its mechanistic contributions to disease and explore its therapeutic potential.
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