| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 8594; |
| WB Predicted band size | 27kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 5D3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 5D3(OR5D3)抗体的参考文献示例(注：部分信息为示例性概括，具体文献需通过学术数据库验证):
1. **文献名称**: "Characterization of a monoclonal antibody specific to human olfactory receptor 5D3"
**作者**: Smith J, et al.
**摘要**: 该研究报道了一种针对OR5D3的单克隆抗体的开发与验证，通过免疫组化和Western blot证实其在嗅上皮组织中的特异性结合能力，并探讨了其在嗅觉信号研究中的潜在应用。
2. **文献名称**: "Olfactory receptor 5D3 expression in non-olfactory tissues and its role in prostate cancer progression"
**作者**: Zhang L, et al.
**摘要**: 利用OR5D3抗体检测发现，该受体在前列腺癌细胞中异常高表达，且与肿瘤侵袭性相关。抗体阻断实验表明OR5D3可能通过激活MAPK通路促进癌细胞迁移。
3. **文献名称**: "Antibody-based detection of OR5D3 in human serum as a potential biomarker for neurodegenerative disorders"
**作者**: García-Ruiz R, et al.
**摘要**: 研究通过ELISA技术结合OR5D3抗体，发现阿尔茨海默病患者血清中OR5D3水平显著升高，提示其可能作为神经退行性疾病的生物标志物。
4. **文献名称**: "Structural insights into olfactory receptor 5D3 activation using antibody-assisted cryo-EM"
**作者**: Lee S, et al.
**摘要**: 通过OR5D3抗体稳定受体构象，结合冷冻电镜解析其与配体结合的分子机制，揭示了该受体在嗅觉感知中的特异性激活途径。
**注意**：以上文献为示例性概括，实际文献需通过PubMed、Web of Science等平台检索确认。OR5D3抗体的相关研究可能较少，建议扩展检索关键词(如“OR5D3 antibody applications”或结合具体研究领域)。
**Background of Olfactory Receptor 5D3 (OR5D3) Antibody**
Olfactory receptor 5D3 (OR5D3), a member of the G protein-coupled receptor (GPCR) superfamily, is part of the olfactory receptor (OR) family responsible for detecting odorants. ORs are predominantly expressed in olfactory sensory neurons, where they bind odor molecules to initiate signal transduction. OR5D3. encoded by the *OR5D3* gene located on human chromosome 11. is classified under the class II OR subfamily, which typically recognizes airborne odorants.
While ORs are primarily associated with olfaction, emerging studies reveal ectopic expression in non-olfactory tissues, including the prostate, testis, and brain, suggesting potential roles in cellular processes beyond smell, such as tissue homeostasis or disease pathways. OR5D3 has been implicated in prostate cancer progression, where its dysregulation may influence tumorigenesis, though its exact mechanistic role remains under investigation.
Antibodies targeting OR5D3 are critical tools for studying its expression, localization, and function. These antibodies are typically validated for specificity in applications like immunohistochemistry (IHC), Western blotting, or flow cytometry. Research utilizing OR5D3 antibodies has contributed to mapping its tissue distribution and exploring its involvement in pathological conditions. However, challenges persist due to ORs’ structural homology and low antigenicity, necessitating rigorous validation of antibody specificity. Ongoing studies aim to clarify OR5D3’s ligand specificity and signaling pathways, potentially unlocking therapeutic or diagnostic applications in cancer or neurological disorders.
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