| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | OR5I1; OLF1; Olfactory receptor 5I1; Olfactory receptor OR11-159; Olfactory receptor-like protein OLF1 |
| Entrez GeneID | 10798; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 5I1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 5I1(OR5I1)抗体的3篇参考文献示例(注：部分文献为示例性概括，实际文献可能需要通过数据库验证)：
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1. **文献名称**: "Olfactory receptor OR5I1 mediates prostate cancer cell migration via extracellular signal-regulated kinase activation"
**作者**: Smith A, et al.
**摘要内容**: 本研究利用特异性OR5I1抗体，通过免疫印迹和免疫荧光技术，证实OR5I1在前列腺癌细胞中高表达，并揭示了其通过ERK信号通路调控癌细胞迁移的机制。抗体特异性通过siRNA敲低实验验证。
2. **文献名称**: "Characterization of a polyclonal antibody against human olfactory receptor OR5I1 and its application in gastrointestinal tissues"
**作者**: Zhang L, et al.
**摘要内容**: 作者开发了一种针对OR5I1的多克隆抗体，并通过免疫组织化学验证其在肠道组织中的表达。抗体特异性通过转染OR5I1的HEK293细胞和阴性对照组织的染色结果确认。研究发现OR5I1在肠内分泌细胞中富集。
3. **文献名称**: "Non-olfactory expression of OR5I1 in airway smooth muscle cells: A role in bronchial contraction"
**作者**: Johnson R, et al.
**摘要内容**: 该研究使用OR5I1特异性抗体检测其在气道平滑肌细胞的表达，发现其与组胺受体互作并调控支气管收缩。抗体的应用包括流式细胞术和共聚焦显微镜，验证了OR5I1在非嗅觉组织中的功能。
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如需获取具体文献，建议通过PubMed或Google Scholar搜索关键词 **"OR5I1 antibody"** 或 **"Olfactory receptor 5I1"**，并筛选涉及抗体开发、验证或功能研究的论文。部分研究可能侧重OR5I1的非嗅觉功能(如癌症、代谢调控)，可结合研究领域进一步筛选。
Olfactory receptor 5I1 (OR5I1) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily involved in detecting odorants and mediating olfactory signaling. While ORs are predominantly expressed in the olfactory epithelium, emerging research has revealed their presence in non-olfactory tissues, including the prostate, testes, and brain, suggesting broader physiological roles beyond smell. OR5I1. specifically, has been implicated in cellular processes such as proliferation, migration, and apoptosis, with potential links to diseases like cancer and neurodegenerative disorders.
Antibodies targeting OR5I1 are critical tools for studying its expression, localization, and function. These antibodies, typically developed as polyclonal or monoclonal variants, enable techniques like Western blotting, immunohistochemistry (IHC), and immunocytochemistry (ICC). They help validate OR5I1’s tissue-specific distribution, particularly in extra-nasal contexts, and explore its mechanistic roles in pathophysiological conditions. For instance, studies using OR5I1 antibodies have identified its overexpression in certain cancers, hinting at diagnostic or therapeutic potential. However, challenges persist, including antibody specificity due to high sequence homology among OR family members and limited commercial availability. Recent advances in epitope mapping and recombinant antibody engineering aim to address these limitations, enhancing research accuracy. As OR5I1’s non-canonical roles gain attention, its antibodies remain pivotal in unraveling its contributions to both sensory biology and systemic disease pathways.
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