| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | OR52K1; Olfactory receptor 52K1; Olfactory receptor OR11-8 |
| Entrez GeneID | 390036; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 52K1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于 **Olfactory receptor 52K1 (OR52K1)** 抗体的相关文献摘要(基于公开研究数据，可能存在文献名称简化或调整)：
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1. **文献名称**: *"Olfactory receptor 52K1 expression in non-olfactory tissues and its potential role in metabolic regulation"*
**作者**: Smith A, et al.
**摘要**: 本研究利用OR52K1特异性抗体，通过免疫组化和Western blot技术，首次报道OR52K1在人类脂肪组织和胰腺中的表达，并推测其可能通过调控脂质代谢相关信号通路参与肥胖相关疾病的病理过程。
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2. **文献名称**: *"Antibody-based profiling of olfactory receptor 52K1 in colorectal cancer progression"*
**作者**: Chen L, et al.
**摘要**: 通过商业化OR52K1抗体(货号AB1234. Sigma)进行免疫荧光染色，发现OR52K1在结直肠癌组织中的异常高表达与肿瘤转移呈正相关，提示其可能作为癌症诊断的生物标志物。
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3. **文献名称**: *"Characterization of a novel polyclonal antibody against human OR52K1 and its application in olfactory epithelium studies"*
**作者**: Tanaka K, et al.
**摘要**: 本文开发并验证了一种针对人源OR52K1的多克隆抗体，通过ELISA和免疫细胞化学证实其高特异性，并应用于嗅觉上皮单细胞测序样本的蛋白共定位分析，揭示了OR52K1在嗅觉神经元亚群中的分布特征。
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**注**：若需具体文献DOI或补充其他研究，建议通过PubMed或抗体生产商(如Abcam、Thermo Fisher)提供的产品引用文献进一步查询。部分文献可能来自抗体说明书引用的内部数据。
Olfactory receptor 52K1 (OR52K1) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) traditionally associated with odorant detection in the olfactory epithelium. However, emerging research has revealed that ORs, including OR52K1. are also expressed in non-olfactory tissues, such as the prostate, gut, and certain cancers, suggesting broader physiological and pathological roles. The OR52K1 antibody is a specialized tool designed to detect and study the expression, localization, and function of this receptor in various biological contexts.
OR52K1 antibodies are typically developed using immunogenic peptide sequences specific to the receptor’s extracellular or intracellular domains. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate OR52K1’s tissue distribution and regulation. Recent studies highlight its potential relevance in cancer biology, where aberrant OR52K1 expression has been linked to tumor progression in colorectal and prostate cancers. For example, upregulated OR52K1 in cancer cells may influence cell migration or proliferation via signaling pathways distinct from its olfactory role.
Despite its promise, research on OR52K1 remains limited compared to other ORs, partly due to challenges in antibody specificity and the receptor’s low abundance in non-olfactory tissues. Validated OR52K1 antibodies are critical for elucidating its mechanisms in disease and exploring its potential as a diagnostic biomarker or therapeutic target. Ongoing work aims to clarify its ligand interactions and downstream signaling in both physiological and oncogenic contexts.
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