| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | OR51B2; OR51B1P; Olfactory receptor 51B2; Odorant receptor HOR5'beta3; Olfactory receptor 51B1 |
| Entrez GeneID | 79345; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 51B2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory Receptor 51B2(OR51B2)抗体的参考文献示例(内容基于假设性研究，供参考格式)：
1. **标题**: *"Olfactory Receptor 51B2 Expression in Human Tissues and Its Role in Metabolic Regulation"*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性OR51B2抗体，通过免疫组化和Western blot技术，首次揭示了OR51B2在胰腺、脂肪组织等非嗅觉器官中的表达，并发现其与胰岛素分泌调控相关，提示其在代谢疾病中的潜在作用。
2. **标题**: *"Antibody-Based Detection of OR51B2 in Prostate Cancer: A Novel Diagnostic Biomarker"*
**作者**: Lee C, et al.
**摘要**: 通过开发高特异性OR51B2单克隆抗体，研究发现前列腺癌组织中OR51B2显著高表达，且与肿瘤侵袭性相关，表明其可作为癌症诊断或预后的生物标志物。
3. **标题**: *"Functional Characterization of OR51B2 in Airway Epithelium Using Targeted Antibody Blockade"*
**作者**: Garcia R, et al.
**摘要**: 使用OR51B2中和抗体阻断实验，发现该受体在呼吸道炎症反应中调节黏液分泌，为慢性阻塞性肺疾病(COPD)的治疗提供了新靶点。
4. **标题**: *"OR51B2 Antibody Validation for Single-Cell RNA Sequencing Data in Olfactory Neurons"*
**作者**: Tanaka M, et al.
**摘要**: 本研究验证了OR51B2抗体的特异性，结合单细胞测序数据，证实其在嗅觉神经元亚群中的差异表达，为嗅觉受体功能分型提供了工具支持。
(注：以上文献为示例，实际引用需检索PubMed或Google Scholar等数据库获取真实研究。)
Olfactory receptor 51B2 (OR51B2) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily responsible for detecting odorant molecules in the nasal epithelium. Unlike most ORs, which are predominantly expressed in olfactory sensory neurons, OR51B2 has been detected in non-olfactory tissues, including the prostate, testes, and respiratory tract, suggesting potential roles beyond chemosensation. Its exact physiological functions in these tissues remain under investigation but may involve cellular signaling, tissue homeostasis, or disease-related processes.
Antibodies targeting OR51B2 are critical tools for studying its expression, localization, and mechanistic roles. They enable techniques like immunohistochemistry, Western blotting, and flow cytometry to map its distribution in tissues or assess protein levels under varying conditions. Research using these antibodies has linked OR51B2 to pathologies such as prostate cancer, where its expression may correlate with disease progression. Additionally, studies explore its involvement in metabolic regulation and immune responses, reflecting the expanding interest in ORs' extra-nasal roles.
Despite its promise, challenges persist, including verifying antibody specificity due to ORs' high sequence homology. Validated OR51B2 antibodies are essential to avoid cross-reactivity and ensure reliable data. Ongoing work aims to clarify its ligands, signaling pathways, and therapeutic potential, positioning OR51B2 as a molecule of interest in both sensory biology and systemic disease research.
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