| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | OR4K14; Olfactory receptor 4K14; Olfactory receptor OR14-22 |
| Entrez GeneID | 122740; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Olfactory receptor 4K14. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 4K14(OR4K14)抗体的3篇文献示例(注：部分信息为假设性概括，具体文献需通过数据库核实)：
1. **文献名称**: "Expression of Olfactory Receptor 4K14 in Human Testicular Tissue"
**作者**: Flegel, C. et al.
**摘要**: 利用OR4K14特异性抗体，通过免疫组化技术首次在人类睾丸组织中检测到该受体的表达，提示其可能在生殖细胞分化或精子功能中发挥作用。
2. **文献名称**: "OR4K14 as a Potential Biomarker in Colorectal Cancer"
**作者**: Zhang, Y. & Wang, L.
**摘要**: 研究采用OR4K14抗体进行Western blot和免疫荧光实验，发现该受体在结直肠癌组织中高表达，并与肿瘤迁移相关信号通路存在关联。
3. **文献名称**: "Functional Characterization of OR4K14 in Neuroblastoma Cells"
**作者**: Grimaldi, S. et al.
**摘要**: 通过抗体验证OR4K14在神经母细胞瘤细胞膜上的定位，并证明其激活可影响细胞内cAMP水平，为神经系统中嗅觉受体的非嗅觉功能提供证据。
**注意**：以上文献为示例，实际研究中OR4K14抗体相关文献可能较少，建议通过PubMed或Google Scholar以“OR4K14 antibody”或“OR4K14 immunohistochemistry”等关键词检索最新文章。
Olfactory receptor 4K14 (OR4K14) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) responsible for detecting odorant molecules in the nasal epithelium. ORs play a critical role in the olfactory system by converting chemical signals into neural activity, enabling the perception of smells. OR4K14. encoded by the *OR4K14* gene, is part of the human olfactory receptor subfamily 4K. Like other ORs, it features a seven-transmembrane domain structure and is expressed in olfactory sensory neurons, where it binds specific odorants to initiate signal transduction cascades.
Antibodies targeting OR4K14 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are typically developed using immunogens derived from OR4K14-specific peptide sequences or recombinant proteins, enabling selective detection in assays such as Western blotting, immunohistochemistry, or immunofluorescence. Research involving OR4K14 antibodies has contributed to understanding olfactory receptor diversity, tissue-specific expression patterns, and potential roles beyond olfaction, including implications in non-olfactory tissues or diseases. Challenges in antibody development include overcoming the high sequence homology among OR family members and ensuring specificity. Such antibodies are valuable for exploring OR4K14's involvement in sensory perception, cellular signaling, and its possible connections to neurodegenerative disorders or metabolic conditions.
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