| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | OR52E4; Olfactory receptor 52E4; Olfactory receptor OR11-55 |
| Entrez GeneID | 390081; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 52E4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于Olfactory receptor 52E4(OR52E4)抗体的3篇参考文献的简要概括(注：文献为虚构示例，实际引用需核实)：
1. **《Olfactory receptor 52E4 is expressed in human testis and modulates germ cell function》**
- 作者：Zhang, Y. et al.
- 摘要：本研究通过OR52E4特异性抗体发现该受体在人类睾丸组织中的表达，并揭示其可能通过调节cAMP信号通路影响精子活力。
2. **《OR52E4 as a novel biomarker in psoriasis: Antibody-based detection in skin tissue》**
- 作者：Flegel, C. et al.
- 摘要：利用抗OR52E4抗体检测银屑病患者皮肤样本，发现该受体在表皮层异常高表达，可能与炎症反应和角质形成细胞增殖相关。
3. **《Antibody targeting of OR52E4 reveals its oncogenic role in breast cancer progression》**
- 作者：Kang, H. & Smith, R.
- 摘要：通过免疫组化(OR52E4抗体)证实其在乳腺癌细胞中高表达，敲低OR52E4可抑制肿瘤迁移，提示其作为潜在治疗靶点。
4. **《Olfactory receptor 52E4 antibody validation for non-olfactory tissues》**
- 作者：Saito, H. et al.
- 摘要：系统验证了OR52E4抗体的特异性，确认其在肺、前列腺等非嗅觉组织中的表达，并探讨其与细胞增殖调控的关联。
建议通过PubMed或Google Scholar输入关键词“OR52E4 antibody”或“OR52E4 function”获取真实文献。
Olfactory receptor 52E4 (OR52E4) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily involved in detecting odorants in the nasal epithelium. However, emerging research highlights their ectopic expression in non-olfactory tissues, suggesting roles in physiological and pathological processes such as cancer progression, cell migration, and hormone regulation. OR52E4. encoded by the OR52E4 gene on human chromosome 11. is classified within the OR52 subfamily. While its precise biological function remains unclear, studies have detected its expression in tissues like the prostate, linking it to diseases such as prostate cancer, where it may serve as a biomarker or therapeutic target.
Antibodies targeting OR52E4 are critical tools for investigating its localization, expression patterns, and mechanistic roles. These antibodies enable techniques like immunohistochemistry, Western blotting, and flow cytometry to map OR52E4 distribution in healthy versus diseased tissues. For example, OR52E4 upregulation in certain cancers has spurred interest in its diagnostic or prognostic potential. Challenges include ensuring antibody specificity due to high sequence homology among OR family members and low endogenous protein levels in non-olfactory tissues. Current research focuses on validating these antibodies for reliability in diverse experimental models, paving the way for deeper insights into OR52E4’s functional significance and its exploitation in biomedical applications.
×
